In the present study, we wanted to review the role of cannabinoids in learning and memory in animal models, with respect to their interaction effects with six principal neurotransmitters involved in learning and memory including dopamine, glutamate, GABA (γ-aminobutyric acid), serotonin, acetylcholine, and noradrenaline. Cannabinoids induce a wide-range of unpredictable effects on cognitive functions, while their mechanisms are not fully understood. Cannabinoids in different brain regions and in interaction with different neurotransmitters, show diverse responses. Previous findings have shown that cannabinoids agonists and antagonists induce various unpredictable effects such as similar effect, paradoxical effect, or dualistic effect. It should not be forgotten that brain neurotransmitter systems can also play unpredictable roles in mediating cognitive functions. Thus, we aimed to review and discuss the effect of cannabinoids in interaction with neurotransmitters on learning and memory. In addition, we mentioned to the type of interactions between cannabinoids and neurotransmitter systems. We suggested that investigating the type of interactions is a critical neuropharmacological issue that should be considered in future studies.

在本研究中，我们想回顾大麻素在动物模型中的学习和记忆中的作用，以及它们与参与学习和记忆的六种主要神经递质的相互作用，包括多巴胺，谷氨酸，GABA（γ-氨基丁酸），5-羟色胺，乙酰胆碱和去甲肾上腺素。大麻素对认知功能会产生各种无法预测的影响，但其机理尚未完全了解。不同大脑区域中的大麻素以及与不同神经递质相互作用的大麻素显示出不同的反应。先前的发现表明，大麻素激动剂和拮抗剂会引起各种不可预测的作用，例如相似作用，悖论作用或二元作用。不应忘记，大脑神经递质系统在介导认知功能方面也可能发挥不可预测的作用。因此，我们旨在审查和讨论大麻素与神经递质相互作用对学习和记忆的影响。此外，我们提到了大麻素与神经递质系统之间相互作用的类型。我们建议调查相互作用的类型是一个重要的神经药理学问题，应在以后的研究中予以考虑。