Growth hormone (GH) actions via initiating cell signalling through the GH receptor (GHR) is important for many physiological processes, in addition to its well-known role in regulating growth. The activation of JAK-STAT signalling by GH is well characterized, however knowledge on GH activation of SRC family kinases (SFKs) is still limited. In this review we summarise the collective knowledge on the activation, regulation, and downstream signalling of GHR. We highlight studies on GH activation of SFKs and the important outcome of this signalling pathway with a focus on the different degradation mechanisms that can regulate GHR availability since this is an area that warrants further study considering its role in tumour progression.

除了众所周知的调节生长的作用外，生长激素 (GH) 通过 GH 受体 (GHR) 启动细胞信号传导对许多生理过程很重要。GH 对 JAK-STAT 信号的激活得到了很好的表征，但是关于 SRC 家族激酶 (SFK) 的 GH 激活的知识仍然有限。在这篇综述中，我们总结了关于 GHR 激活、调节和下游信号传导的集体知识。我们重点介绍了关于 SFK 的 GH 激活和该信号通路的重要结果的研究，重点是可以调节 GHR 可用性的不同降解机制，因为考虑到其在肿瘤进展中的作用，这是一个值得进一步研究的领域。