Atrial fibrillation (AF) is a common arrhythmia in the general population and following cardiac surgery. The influence of mitochondrial genomics on AF pathogenesis is not fully understood. We analyzed mitochondrial variables from 78 human atrial samples collected from cardiac surgeries in the following groups: 1) permanent preoperative AF; 2) preoperative sinus rhythm (SR) with postoperative AF; and 3) pre-/postoperative SR. Haplogroup H appeared offer protection against, and haplogroup U predispose to permanent AF. mtDNA content was higher in group 2 than in 3. These findings contribute to a better understanding of the influence of mitochondria on AF pathogenesis.

中文翻译：

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线粒体遗传对心房颤动的影响：病例对照研究

心房颤动 (AF) 是普通人群和心脏手术后常见的心律失常。线粒体基因组学对 AF 发病机制的影响尚不完全清楚。我们分析了从以下几组心脏手术中收集的 78 个人类心房样本的线粒体变量：1) 永久性术前 AF；2）术前窦性心律（SR）伴术后房颤；3) 术前/术后 SR。单倍群 H 出现提供保护，防止和单倍群 U 易患永久性 AF。第 2 组的 mtDNA 含量高于第 ​​3 组。这些发现有助于更好地了解线粒体对 AF 发病机制的影响。