Paracetamol is a non-steroidal, anti-inflammatory drug widely used in pharmaceutical applications for its sturdy, antipyretic and analgesic action. However, an overdose of paracetamol can cause fulminant hepatic necrosis and other toxic effects. Thus, the development of advantageous analytical tools to detect and determine paracetamol is required. Due to simplicity, higher sensitivity and selectivity as well as costefficiency, electrochemical sensors were fully investigated in last decades. This review describes the advancements made in the development of electrochemical sensors for the paracetamol detection and quantification in pharmaceutical and biological samples. The progress made in electrochemical sensors for the selective detection of paracetamol in the last 10 years was examined, with a special focus on highly innovative features introduced by nanotechnology. As the literature is rather extensive, we tried to simplify this work by summarizing and grouping electrochemical sensors according to the by which manner their substrates were chemically modified and the analytical performances obtained.

扑热息痛是一种非甾体类抗炎药，因其结实，解热和镇痛作用而广泛用于制药应用。然而，过量的扑热息痛可能引起暴发性肝坏死和其他毒性作用。因此，需要开发用于检测和确定对乙酰氨基酚的有利分析工具。由于简单，更高的灵敏度和选择性以及成本效益，最近几十年来对电化学传感器进行了全面研究。这篇综述描述了用于对乙酰氨基酚检测和定量的药物和生物样品电化学传感器的开发进展。研究了过去十年中用于选择性检测扑热息痛的电化学传感器的进展，特别关注纳米技术带来的高度创新的功能。随着文献的广泛使用，我们试图根据电化学传感器的底物经过化学修饰的方式以及获得的分析性能，通过对电化学传感器进行归纳和分组来简化这项工作。