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Synthesis of Pluronic F127-coated Magnesium/Calcium (Mg1-xCaxFe2O4) magnetic nanoparticles for biomedical applications
Journal of Magnetism and Magnetic Materials ( IF 2.5 ) Pub Date : 2021-03-01 , DOI: 10.1016/j.jmmm.2020.167518
Pamela Yajaira Reyes-Rodríguez , Dora Alicia Cortés-Hernández , Carlos Alberto Ávila-Orta , Javier Sánchez , Marlene Andrade-Guel , Adán Herrera-Guerrero , Christian Cabello-Alvarado , Víctor Hugo Ramos-Martínez

Abstract Magnetic nanoparticles are promising materials for biomedical applications such as hyperthermia treatment. In this study, the synthesis of Mg1-xCaxFe2O4, x=0.0-0.9 nanoparticles, and coating with Pluronic F127 was carried out and evaluated as possible candidates for magnetic hyperthermia applications. The nanoparticles were synthesized by the thermal decomposition method using metallic salts of Fe, Mg, and Ca in the form of acetylacetonates. The crystalline structure and the magnetic properties of the samples due to the substitution of Mg2+ by Ca2+ in the synthesized samples were evaluated. The samples possess an inverse spinel structure, and the lattice parameter increased as the substitution of Ca2+ ions took place. Vibration sample magnetometry (VSM) was used to evaluate the magnetic properties and to quantify the saturation magnetization (Ms), the remnant magnetization (Mr), and the coercive field (Hc) of the samples. The morphology was quasi-spherical, and their average size was less than 10 nm as determined by transmission electron microscopy (TEM). The heating ability of selected Pluronic F-127 coated ferrites indicate that the nanoparticles can increase the medium temperature up to 42°C in a time of 7 min. Hemolysis values were less than 2.5% for all evaluated samples, indicating no cytotoxic effect on the red blood cells. The presented results allow indicating that the nanoparticles of Mg0.9Ca0.1Fe2O4 are candidates for their potential use as thermoseeds for magnetic hyperthermia treatment.

中文翻译:

用于生物医学应用的 Pluronic F127 涂层镁/钙 (Mg1-xCaxFe2O4) 磁性纳米粒子的合成

摘要 磁性纳米粒子是用于生物医学应用(如热疗)的有前途的材料。在这项研究中,合成了 Mg1-xCaxFe2O4、x=0.0-0.9 纳米颗粒,并用 Pluronic F127 涂层进行了评估,并将其作为磁热疗应用的可能候选物进行了评估。纳米粒子是通过热分解法使用乙酰丙酮化物形式的 Fe、Mg 和 Ca 金属盐合成的。由于合成样品中的 Mg2+ 被 Ca2+ 取代,因此评估了样品的晶体结构和磁性能。样品具有反尖晶石结构,晶格参数随着 Ca2+ 离子的取代而增加。振动样品磁力计 (VSM) 用于评估磁性并量化样品的饱和磁化强度 (Ms)、剩余磁化强度 (Mr) 和矫顽磁场 (Hc)。形态为准球形,通过透射电子显微镜 (TEM) 确定它们的平均尺寸小于 10 nm。选定的 Pluronic F-127 涂层铁氧体的加热能力表明,纳米颗粒可以在 7 分钟内将介质温度升高至 42°C。所有评估样品的溶血值均小于 2.5%,表明对红细胞没有细胞毒性作用。所呈现的结果表明,Mg0.9Ca0.1Fe2O4 纳米颗粒是其潜在用途的候选者,可用作磁热疗的热种子。和样品的矫顽场 (Hc)。形态为准球形,通过透射电子显微镜 (TEM) 确定它们的平均尺寸小于 10 nm。选定的 Pluronic F-127 涂层铁氧体的加热能力表明,纳米颗粒可以在 7 分钟内将介质温度升高至 42°C。所有评估样品的溶血值均小于 2.5%,表明对红细胞没有细胞毒性作用。所呈现的结果表明,Mg0.9Ca0.1Fe2O4 纳米颗粒是其潜在用途的候选者,可用作磁热疗的热种子。和样品的矫顽场 (Hc)。形态为准球形,通过透射电子显微镜 (TEM) 确定它们的平均尺寸小于 10 nm。选定的 Pluronic F-127 涂层铁氧体的加热能力表明,纳米颗粒可以在 7 分钟内将介质温度升高至 42°C。所有评估样品的溶血值均小于 2.5%,表明对红细胞没有细胞毒性作用。所呈现的结果表明,Mg0.9Ca0.1Fe2O4 纳米颗粒是其潜在用途的候选者,可用作磁热疗的热种子。选定的 Pluronic F-127 涂层铁氧体的加热能力表明,纳米颗粒可以在 7 分钟内将介质温度升高至 42°C。所有评估样品的溶血值均小于 2.5%,表明对红细胞没有细胞毒性作用。所呈现的结果表明,Mg0.9Ca0.1Fe2O4 纳米颗粒是其潜在用途的候选者,可用作磁热疗的热种子。选定的 Pluronic F-127 涂层铁氧体的加热能力表明,纳米颗粒可以在 7 分钟内将介质温度升高至 42°C。所有评估样品的溶血值均小于 2.5%,表明对红细胞没有细胞毒性作用。所呈现的结果表明,Mg0.9Ca0.1Fe2O4 纳米颗粒是其潜在用途的候选者,可用作磁热疗的热种子。
更新日期:2021-03-01
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