Evolutionarily conserved highly regulated process of apoptosis has been a major physiological process throughout the entire evolutionary history of living beings that has impacted the process of evolution itself. One of the key features of this highly researched field of science is the process of phosphatidylserine (PS) externalization by the different membrane bound enzymes. The process is a result of series of biological events and is associated with various biological outcomes depending on the proper recognition of this ligand. In this review, we will briefly summarize the recent advancement in the field pertaining to the set of receptors, known as TAM (Tyro3, Axl and Mertk) receptors, for their influence in the recognition of various PS externalization events and mediation of pathological outcomes such as autoimmunity, cancer, and tissue repair.

进化上保守的高度调控的细胞凋亡过程是贯穿生物整个进化历史的一个主要生理过程，它影响了进化过程本身。这一高度研究的科学领域的关键特征之一是不同膜结合酶将磷脂酰丝氨酸 (PS) 外化的过程。该过程是一系列生物事件的结果，并与各种生物结果相关，具体取决于对该配体的正确识别。在这篇综述中，我们将简要总结与一组受体（称为 TAM（Tyro3、Axl 和 Mertk）受体）有关的领域的最新进展，因为它们在识别各种 PS 外化事件和调节病理结果方面的影响，例如如自身免疫、癌症、