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Cadmium chloride-induced transgenerational neurotoxicity in zebrafish development
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-11-07 , DOI: 10.1016/j.etap.2020.103545
Jingjing Tian , Jia Hu , Di Liu , Jian Yin , Mingli Chen , Lianqun Zhou , Huancai Yin

As an important environmental pollutant, the heavy metal cadmium has a significant negative impact on the stability of the ecological environment and on organismal health. Previous studies have shown that cadmium chloride can damage the nervous, skeletal, endocrine, and reproductive systems, but to our knowledge, the effects of cadmium on the behavior, neurotransmitter levels, and neuronal development in the offspring of exposed animals have not been reported. In the present study, sexually-mature zebrafish were exposed to cadmium chloride at different concentrations for 60 days, and in this background, behavior, neurotransmitters level, neuro-development and neurotransmitter metabolism was investigated in the F1 offspring. The results showed that exposure of the parental zebrafish to cadmium chloride resulted swimming speed and distance of F1 offspring significantly reduced; the levels of neurotransmitters, such as dopamine, serotonin, and acetylcholine is disrupted. neuro-development and neurotransmitter metabolism related genes expression pattern was altered, which cause zebrafish F1 offspring developmental neurotoxicity. These findings provide further insights into the harm posed by cadmium chloride to the aquatic ecosystems.



中文翻译:

氯化镉诱导斑马鱼发育中的跨代神经毒性

作为一种重要的环境污染物,重金属镉对生态环境的稳定性和生物健康具有重大的负面影响。先前的研究表明,氯化镉会损害神经,骨骼,内分泌和生殖系统,但据我们所知,镉对裸露动物后代的行为,神经递质水平和神经元发育的影响尚未见报道。在本研究中,性成熟的斑马鱼暴露于不同浓度的氯化镉中60天,在这种背景下,对F1后代的行为,神经递质水平,神经发育和神经递质代谢进行了研究。结果表明,亲代斑马鱼暴露于氯化镉导致游泳速度和F1后代的距离显着降低;多巴胺,5-羟色胺和乙酰胆碱等神经递质的水平受到破坏。神经发育和神经递质代谢相关基因的表达方式发生改变,引起斑马鱼F1后代发育神经毒性。这些发现为氯化镉对水生生态系统的危害提供了进一步的见解。

更新日期:2020-11-15
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