The mechanisms by which PD-1/PD-L1 inhibition elicits anti-tumor immunity are not fully understood. In this issue of Cancer Cell, Dammeijer et al. address the role of PD-L1 inhibition specifically within the tumor-draining lymph node, identifying a potential role for PD-L1 expressing dendritic cells within the lymph node in regulation of anti-tumor immune responses.

中文翻译：

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PD-L1封锁疗法：位置，位置，位置

PD-1 / PD-L1抑制引发抗肿瘤免疫的机制尚未完全了解。在本期《癌细胞》中，Dammeijer等人。解决了PD-L1抑制作用特别是在引流肿瘤的淋巴结内的作用，确定了淋巴结内表达PD-L1的树突状细胞在调节抗肿瘤免疫反应中的潜在作用。