BACKGROUND The Center for Disease Control (CDC) recently named childhood abuse histories as a public health risk. Clear links between abuse histories and inflammation exist. However, it remains unknown how abuse histories impact inflammatory trajectories throughout adulthood. Accordingly, this study assessed inflammatory trajectories across three visits among healthy adults with and without abuse histories. METHOD In this secondary analysis of data from a longitudinal observational study of cancer survivors and noncancer controls, 157 noncancer controls (Mage = 55.8, range = 32 - 83) completed the Childhood Experiences Questionnaire (CTQ), providing data on physical, emotional, and sexual abuse prior to age 18. Cytokines interleukin-6 (IL-6), interleukin 1-beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) were collected at the baseline visit and two follow-up visits approximately one (M months = 11.52, SD = 4.10) and two years (M months = 23.79, SD = 4.40) later. To represent inflammatory changes, cytokine data at each visit were combined into a composite z-score. . Covariates in all analyses included age, biological sex, race, income, body mass index, menopause status, psychological diagnosis history, and medical comorbidities. RESULTS Compared to their nonabused peers, those who had experienced any type of abuse in childhood demonstrated steeper rises in inflammation across time. Inflammation rose more steeply for individuals with physical and emotional abuse histories compared to those without such histories. CONCLUSION Overall, these data suggest that childhood abuse histories may quicken age-related increases in inflammation, contributing to accelerated aging, morbidity, and early mortality. These findings provide mechanistic insight into why child abuse is a public health risk.

中文翻译：

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童年虐待历史预测随着时间的推移更陡峭的炎症轨迹

背景 疾病控制中心 (CDC) 最近将儿童虐待史命名为公共健康风险。滥用历史和炎症之间存在明确的联系。然而，虐待历史如何影响整个成年期的炎症轨迹仍然未知。因此，本研究评估了有和没有虐待史的健康成年人在三次就诊中的炎症轨迹。方18 岁之前的性虐待。细胞因子白细胞介素 6 (IL-6)、白细胞介素 1-β (IL-1β)、在基线访问和大约一年（M 个月 = 11.52，SD = 4.10）和两年（M 个月 = 23.79，SD = 4.40）之后的两次随访中收集了肿瘤坏死因子-α (TNF-α)。为了代表炎症变化，每次访问的细胞因子数据都被组合成一个复合 z 分数。. 所有分析中的协变量包括年龄、生理性别、种族、收入、体重指数、绝经状态、心理诊断史和合并症。结果 与未受虐待的同龄人相比，那些在童年时期经历过任何类型虐待的人随着时间的推移表现出炎症的急剧上升。与没有这种历史的人相比，有身体和情感虐待历史的人的炎症上升得更快。结论 总体而言，这些数据表明，儿童虐待史可能会加速与年龄相关的炎症增加，从而加速衰老、发病率和早期死亡率。这些发现为为什么虐待儿童是一种公共卫生风险提供了机制性的见解。