Patients with chronic pain report decreased general activity and emotional distress. Therefore, the development of various animal models that encompass different aspects of pain are crucial for the discovery of genetic differences and the assessment of novel analgesics to improve quality of life. C57BL/6J and DBA/2J mice received unilateral intraplantar injections of 100 % CFA, paclitaxel, or CCI surgery to compare their distance traveled in a voluntary wheel running assay, paw edema diameter, and mechanical sensitivity. Mechanical withdrawal thresholds were lower in both strains of mice that received CFA when compared to their vehicle. However, a decrease in distance traveled was observed in CFA-treated C57BL/6J but not DBA/2J mice. In a separate group, chemotherapy agent paclitaxel 8 mg/kg, i.p. was administered to both strains of mice to induce CIPN which was confirmed by lower mechanical thresholds in paclitaxel-treated mice compared to vehicle-treated mice. Only female C57BL/6J mice showed attenuation of distance traveled following treatment, whereas male C57BL/6J and DBA/2J mice did not. Lastly, C57BL/6J mice underwent chronic constriction injury (CCI) or sham surgery to observe the impact of another chronic neuropathic pain model in wheel running assay. CCI mice showed a gradual decrease in mechanical withdrawal threshold and a decrease in distance traveled compared to sham 5 days following the procedure. Comparing these chronic inflammatory and neuropathic pain models in different mouse strains may help us better understand genetic differences underlying pain perception and its impact on reflexive and nonreflexive outcome measures.

慢性疼痛患者报告一般活动减少和情绪困扰。因此，开发涵盖疼痛不同方面的各种动物模型对于发现遗传差异和评估新型镇痛药以提高生活质量至关重要。C57BL/6J 和 DBA/2J 小鼠接受单侧足底内注射 100% CFA、紫杉醇或 CCI 手术，以比较它们在自愿轮跑试验中的行进距离、爪水肿直径和机械敏感性。与载体相比，接受 CFA 的两种小鼠的机械戒断阈值均较低。然而，在 CFA 处理的 C57BL/6J 而不是 DBA/2J 小鼠中观察到行进距离的减少。在单独的组中，化疗剂紫杉醇 8 mg/kg，ip 对两种小鼠品系给药以诱导CIPN，与载体处理的小鼠相比，紫杉醇处理的小鼠的机械阈值较低证实了这一点。只有雌性 C57BL/6J 小鼠在治疗后显示出距离衰减，而雄性 C57BL/6J 和 DBA/2J 小鼠则没有。最后，C57BL/6J 小鼠接受了慢性缩窄性损伤 (CCI) 或假手术，以观察另一种慢性神经性疼痛模型在车轮运行试验中的影响。与手术后 5 天的假手术相比，CCI 小鼠的机械退缩阈值逐渐降低，行进距离减少。比较不同小鼠品系中的这些慢性炎症和神经性疼痛模型可能有助于我们更好地了解疼痛感知背后的遗传差异及其对反射性和非反射性结果测量的影响。