The fabrication of functional tissue or organs substitutes has always been the pursuit of goals in the field of tissue engineering. But even biocompatible tissue-engineered scaffolds still suffer from immune rejection, subsequent long-term oxidative stress and inflammation, which can delay normal tissue repair and regeneration. As a well-known natural antioxidant, polyphenols have been widely used in tissue engineering in recent years. The introduced polyphenols not only reduce the damage of oxidative stress to normal tissues, but show specific affinity to functional molecules, such as receptors, enzyme, transcription and transduction factors, etc. Therefore, polyphenols can promote the recovery process of damaged tissues by both regulating tissue microenvironment and participating in cell events, which embody specifically in antioxidant, anti-inflammatory, antibacterial and growth-promoting properties. In addition, based on its hydrophilic and hydrophobic moieties, polyphenols have been widely used to improve the mechanical properties and anti-degradation properties of tissue engineering scaffolds. In this review, the research advances of tissue engineering scaffolds containing polyphenols is discussed systematically from the aspects of action mechanism, introduction method and regulation effect of polyphenols, in order to provide references for the rational design of polyphenol-related functional scaffolds.

功能组织或器官替代物的制造一直是组织工程领域追求的目标。但是，即使是生物相容的组织工程支架，也仍然遭受免疫排斥，随后的长期氧化应激和炎症的困扰，这会延迟正常组织的修复和再生。作为一种众所周知的天然抗氧化剂，多酚近年来已广泛用于组织工程中。引入的多酚不仅减少了氧化应激对正常组织的损害，而且对功能性分子（如受体，酶，转录和转导因子等）表现出特定的亲和力。因此，多酚可通过两种调节作用来促进受损组织的恢复过程。组织微环境并参与细胞事件，这些事件特别体现在抗氧化剂中，抗炎，抗菌和促进生长的特性。另外，基于其亲水和疏水部分，多酚已被广泛用于改善组织工程支架的机械性能和抗降解性能。本文从多酚的作用机理，引入方法和调控效果等方面系统地探讨了含多酚的组织工程支架的研究进展，为多酚相关功能支架的合理设计提供参考。