Among UV-filters, benzophenones are one of the most abundantly used and detected groups in the environment. Bisphenols are also one of the most widely used chemicals in plastics, but their demonstrated deleterious effects on several organisms and humans have led to the production of alternative analogues. However, few comparative studies on the ecotoxicological effects of these derivatives or analogues have been carried out. The present study aimed to investigate the effects of two benzophenones (BP-3 and BP-4) and two bisphenols (BPA and BPS) in a short-term exposure of the freshwater endobenthic bivalve Corbicula fluminea. Clams were exposed for 96 h to several concentrations of the four pollutants: BP-3 (0.63; 1.25; 2.5; 5 mg l⁻¹), BP-4 (4.75; 9.5; 19; 38 mg l⁻¹), BPA (3.75; 7.5; 15; 30 mg l⁻¹), and BPS (2.5; 5; 10; 20 mg l⁻¹). The comparative acute toxicity of these pollutants was evaluated by the analysis of the post-exposure filtering capacity of clams, lipid peroxidation (LP) levels and the activity of the antioxidant enzymes catalase (CAT) and glutathione reductase (GR). After the exposure period, except for BP-4, the chemicals tested seemed to be detected by clams and provoked valve closure, decreasing filter-feeding in a concentration-dependent manner. Furthermore, C. fluminea exposed to the highest concentrations of BP-3, BP-4 and BPA showed a significant increase in LP, CAT and GR activities with respect to their controls. BP-3 and BPA were the most toxic compounds showing significant differences in all the parameters analysed at the highest concentrations assayed. However, clams exposed to BPS showed only significant alterations in filtration parameters and in GR activity, in the two highest concentrations tested, indicating that this compound was the least toxic to clams. Obtained results highlight the importance of investigating the effects that emerging pollutants have on aquatic organisms.

在紫外线过滤剂中，二苯甲酮是环境中使用最广泛和检测最广泛的基团之一。双酚也是塑料中使用最广泛的化学物质之一，但其对几种生物和人类的有害作用已导致产生替代类似物。然而，关于这些衍生物或类似物的生态毒理作用的比较研究很少。本研究旨在研究两种二苯甲酮（BP-3和BP-4）和两种双酚（BPA和BPS）在淡水底栖贝类双瓣小球藻（Corbicula fluminea）的短期暴露中的作用。将蛤暴露于四种污染物的几种浓度下96小时：BP-3（0.63; 1.25; 2.5; 5 mg l ^-1），BP-4（4.75; 9.5; 19; 38 mg l ^-1），BPA（3.75; 7.5; 15; 30 mg l ^-1）和BPS（2.5; 5; 10; 20 mg l ^-1）。通过对蛤类的接触后过滤能力，脂质过氧化（LP）水平以及抗氧化酶过氧化氢酶（CAT）和谷胱甘肽还原酶（GR）的活性进行分析，评估了这些污染物的相对急性毒性。在暴露期之后，除了BP-4以外，所测试的化学药品似乎被蛤and检测到并引起阀门关闭，从而以浓度依赖的方式减少了过滤器的进料。此外，C。fluminea暴露于最高浓度的BP-3，BP-4和BPA时，与对照组相比，LP，CAT和GR活性显着增加。BP-3和BPA是毒性最高的化合物，在最高浓度下分析的所有参数均显示出显着差异。但是，在两种最高浓度下，暴露于BPS的蛤showed在过滤参数和GR活性方面仅表现出显着变化，表明该化合物对蛤toxic的毒性最低。获得的结果突出了调查新兴污染物对水生生物的影响的重要性。