A three-component reaction for the synthesis of substituted anilines by a gold(I)-catalyzed domino reaction was developed. Cationic gold catalysts selectively and sequentially activated two different alkynes, which were involved in pyrrole synthesis and subsequent Diels–Alder reaction. The sequential formal (3 + 2) annulation/Diels–Alder reaction of three components provided a variety of substituted anilines in a modular fashion. Moreover, utility of the aniline products was demonstrated by derivatization to substituted benzoxazines, which are pharmaceutically important heterocycles.

中文翻译：

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通过金催化的三组分反应合成取代的苯胺

开发了一种三组分反应，用于通过金（I）催化的多米诺骨牌反应合成取代的苯胺。阳离子金催化剂选择性和顺序地活化了两个不同的炔烃，它们参与了吡咯的合成和随后的Diels-Alder反应。三种组分的顺序形式（3 + 2）正环化/ Diels-Alder反应以模块化的方式提供了多种取代苯胺。此外，苯胺产品的实用性通过衍生为取代的苯并恶嗪而得到证明，后者是药学上重要的杂环。