Background The Reelin (RELN) gene encodes the protein reelin, which is a large extracellular matrix glycoprotein that plays a key role in brain development. Additionally, this protein may be involved in memory formation, neurotransmission, and synaptic plasticity, which have been shown to be disrupted in schizophrenia (SCZ). A decreasing trend in the expression of RELN mRNA in the brain and peripheral blood of SCZ patients has been observed. There is a need to determine whether changes in RELN mRNA expression in SCZ patients are the result of long-term antipsychotic treatment rather than the etiological characteristics of schizophrenia. The expression levels of RELN mRNA in the peripheral blood of 48 healthy controls and 30 SCZ patients before and after 12-weeks of treatment were measured using quantitative real-time PCR. Results The expression levels of RELN mRNA in the SCZ group were significantly lower than that of healthy controls; however, after 12-weeks of antipsychotic treatment, RELN mRNA levels were significantly increased in the SCZ group. Conclusion The up-regulation of RELN mRNA expression was current in SCZ patients after antipsychotic treatment, suggesting that the changes in RELN mRNA expression were related to the effect of the antipsychotic treatment.

中文翻译：

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精神分裂症患者抗精神病治疗前后外周血RELN mRNA表达水平的探讨

背景 Reelin (RELN) 基因编码蛋白质 reelin，这是一种大型细胞外基质糖蛋白，在大脑发育中起关键作用。此外，这种蛋白质可能与记忆形成、神经传递和突触可塑性有关，这些已被证明在精神分裂症 (SCZ) 中被破坏。已观察到 SCZ 患者脑和外周血中 RELN mRNA 的表达呈下降趋势。需要确定 SCZ 患者 RELN mRNA 表达的变化是否是长期抗精神病药物治疗的结果，而不是精神分裂症的病因特征。采用定量实时PCR检测治疗前后48例健康对照者和30例SCZ患者外周血RELN mRNA的表达水平。结果 SCZ组RELN mRNA表达水平显着低于健康对照组；然而，经过 12 周的抗精神病治疗后，SCZ 组的 RELN mRNA 水平显着增加。结论 SCZ患者抗精神病治疗后RELN mRNA表达上调，提示RELN mRNA表达的变化与抗精神病治疗效果有关。