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The preparation and applications of amides using electrosynthesis
Green Chemistry ( IF 9.3 ) Pub Date : 2020-11-02 , DOI: 10.1039/d0gc02976a Peter W. Seavill 1, 2, 3, 4 , Jonathan D. Wilden 1, 2, 3, 4
Green Chemistry ( IF 9.3 ) Pub Date : 2020-11-02 , DOI: 10.1039/d0gc02976a Peter W. Seavill 1, 2, 3, 4 , Jonathan D. Wilden 1, 2, 3, 4
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The synthesis of amides is extremely important given the ubiquitous presence of this motif in biological systems, as well as in the pharmaceutical industry, where it is estimated that amide preparation is the most common chemical reaction employed. As such, greener routes to this motif have long been a vital research goal. Amide groups are also synthetically versatile, capable of taking part in a wide range of different transformations, especially when subjected to electrochemical conditions. The current resurgence of electrosynthesis has led to new and more sustainable syntheses of (and using) amides to be published in recent times. As such, this tutorial review aims to highlight these reactions. Given the vital importance of amides and the growing interest in electrosynthesis, the combination of these two topics is an exciting and interesting field of research that holds a lot of promise in the future of synthetic chemistry.
中文翻译：
电合成酰胺的制备及应用
鉴于在生物系统以及制药行业中普遍存在该基序，因此酰胺的合成极为重要。据估计，在制药行业中，酰胺的制备是最常用的化学反应。因此，更绿色的途径一直是该主题的重要研究目标。酰胺基团也是合成通用的，能够参与各种不同的转化，特别是在电化学条件下。当前电合成的复兴导致近来出版了新的和更具可持续性的（和使用）酰胺合成方法。因此，本教程复习旨在突出这些反应。鉴于酰胺的至关重要性以及对电合成的日益增长的兴趣，
更新日期：2020-11-06
中文翻译：
电合成酰胺的制备及应用
鉴于在生物系统以及制药行业中普遍存在该基序，因此酰胺的合成极为重要。据估计，在制药行业中，酰胺的制备是最常用的化学反应。因此，更绿色的途径一直是该主题的重要研究目标。酰胺基团也是合成通用的，能够参与各种不同的转化，特别是在电化学条件下。当前电合成的复兴导致近来出版了新的和更具可持续性的（和使用）酰胺合成方法。因此，本教程复习旨在突出这些反应。鉴于酰胺的至关重要性以及对电合成的日益增长的兴趣，
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