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Multifunctional Transferrin Encapsulated GdF3 Nanoparticles for Sentinel Lymph Node and Tumor Imaging
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-11-06 , DOI: 10.1021/acs.bioconjchem.0c00514 Xudong Shi 1 , Kai Gao 1 , Shaoqing Xiong 1 , Ran Gao 1
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-11-06 , DOI: 10.1021/acs.bioconjchem.0c00514 Xudong Shi 1 , Kai Gao 1 , Shaoqing Xiong 1 , Ran Gao 1
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The transferrin encapsulated GdF3 nanoparticles have been fabricated via biomineralization method. The obtained GdF3@Tf NPs show an attractive T2MRI and CT enhancement effect. Furthermore, PET and NIR imaging capacity are integrated into nanoparticles through conjugating with radionuclide 64Cu and fluorescent dye Cy7. 64Cu-GdF3@Tf-Cy7 NPs are developed and applied in small animal multimodal imaging in vivo. Compared with the previous multimodal imaging agents, 64Cu-GdF3@Tf-Cy7 NPs enable not only precise sentinel lymph node (SLN) identification, but specific imaging for transferrin receptor overexpressed colorectal tumor in vivo. The results reveal that 64Cu-GdF3@Tf-Cy7 NPs are potential and efficient multimodal imaging agents for SLN and tumor preclinical imaging.
中文翻译：
多功能转铁蛋白封装的GdF 3纳米粒子的前哨淋巴结和肿瘤成像。
通过生物矿化方法已经制备了转铁蛋白包封的GdF 3纳米颗粒。所获得的GdF 3 @Tf NPs具有诱人的T2MRI和CT增强作用。此外，PET和NIR成像能力通过与放射性核素64 Cu和荧光染料Cy7结合而整合到纳米颗粒中。开发了64个Cu-GdF 3 @ Tf-Cy7 NP，并将其应用于体内小动物多峰成像。与以前的多峰成像剂相比，64 Cu-GdF 3 @ Tf-Cy7 NPs不仅可以精确地识别前哨淋巴结（SLN），而且可以对转铁蛋白受体过表达的结直肠肿瘤进行特异性成像体内。结果表明，64个Cu-GdF 3 @ Tf-Cy7 NPs是用于SLN和肿瘤临床前成像的潜在且有效的多峰成像剂。
更新日期：2020-11-18
中文翻译：
多功能转铁蛋白封装的GdF 3纳米粒子的前哨淋巴结和肿瘤成像。
通过生物矿化方法已经制备了转铁蛋白包封的GdF 3纳米颗粒。所获得的GdF 3 @Tf NPs具有诱人的T2MRI和CT增强作用。此外，PET和NIR成像能力通过与放射性核素64 Cu和荧光染料Cy7结合而整合到纳米颗粒中。开发了64个Cu-GdF 3 @ Tf-Cy7 NP，并将其应用于体内小动物多峰成像。与以前的多峰成像剂相比，64 Cu-GdF 3 @ Tf-Cy7 NPs不仅可以精确地识别前哨淋巴结（SLN），而且可以对转铁蛋白受体过表达的结直肠肿瘤进行特异性成像体内。结果表明，64个Cu-GdF 3 @ Tf-Cy7 NPs是用于SLN和肿瘤临床前成像的潜在且有效的多峰成像剂。
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