Abstract

Type 2 diabetes mellitus (T2DM) is a worldwide disease with rapidly increasing prevalence. This complex disorder caused by interplay between genetic predisposition factors, early developmental elements, diet and inactive lifestyle. Several researches have shown impact of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the pathogenesis of this disorder. Several miRNAs such as miR-126, miR-222-3p, miR-182, let-7b-5p, and miR-1-3p have been down-regulated in different biological sources of patients with T2DM. Some other miRNAs including miR-21, miR-30d, miR-148a-3p, miR-146b and miR-486 have the opposite trends. In addition, a number of lncRNAs such as LY86-AS, HCG27_201, VIM‐AS1, CTBP1‐AS2, CASC2, GAS5, LINC-PINT, and MALAT1 have been altered in the peripheral blood, serum samples or tissues obtained from patients with T2DM. Taken together, both miRNAs and lncRNAs contribute to the development of T2DM and might be applied as markers or therapeutic molecules for this disorder.

摘要

2 型糖尿病 (T2DM) 是一种世界范围内的疾病，患病率迅速上升。这种复杂的疾病是由遗传易感因素、早期发育因素、饮食和不活跃的生活方式之间的相互作用引起的。一些研究表明长链非编码 RNA (lncRNA) 和 microRNA (miRNA) 在这种疾病的发病机制中的影响。miR-126、miR-222-3p、miR-182、let-7b-5p 和 miR-1-3p 等几种 miRNA 在 T2DM 患者的不同生物来源中被下调。其他一些 miRNA 包括 miR-21、miR-30d、miR-148a-3p、miR-146b 和 miR-486 具有相反的趋势。此外，许多 lncRNA，如 LY86-AS、HCG27_201、VIM-AS1、CTBP1-AS2、CASC2、GAS5、LINC-PINT 和 MALAT1 在 T2DM 患者的外周血、血清样本或组织中发生了改变. 综合起来，