当前位置: X-MOL 学术Synthesis › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
(E)-3-Arylidene-4-diazopyrrolidine-2,5-diones: Preparation and Use in RhII-Catalyzed X–H Insertion Reactions towards Novel, Medicinally Important Michael Acceptors
Synthesis ( IF 2.2 ) Pub Date : 2020-11-05 , DOI: 10.1055/s-0040-1706556
Dmitry Dar’in 1 , Mikhail Krasavin 1, 2 , Evgeny Chupakhin 1 , Martha Gecht 1 , Alexander Ivanov 1 , Grigory Kantin 1
Affiliation  

The use of readily available 1-aryl-3-arylidenepyrrolidine-2,5-diones in high yielding direct diazo-transfer reactions and subsequent involvement of the resulting diazo compounds in RhII-catalyzed O–H, S–H, and N–H insertion reactions delivered 4-substituted 1-aryl-3-arylidenepyrrolidine-2,5-diones of defined regiochemistry and geometrical configuration. These products are intended to be studied as Michael acceptors capable of inhibiting thioredoxin reductase, a promising cancer target.



中文翻译:

(E)-3-亚芳基-4-重氮吡咯烷-2,5-二酮:在RhII催化的X–H插入反应中,对新颖的,具有重要医学意义的迈克尔受体的制备和使用

在高产率的直接重氮转移反应中以及随后的重氮化合物参与Rh II催化的OH,SH和N H插入反应递送了定义的区域化学和几何构型的4-取代的1-芳基-3-亚芳基吡咯烷-2,5-二酮。这些产品拟作为能够抑制硫氧还蛋白还原酶(一种有希望的癌症靶标)的迈克尔受体进行研究。

更新日期:2020-11-06
down
wechat
bug