Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis,Journal of Leukocyte Biology

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Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2020-11-06 , DOI: 10.1002/jlb.3ru0720-418r
Ting Shi ₁ , Laura Denney ₂ , Huazhang An ₃ , Ling-Pei Ho ₂ , Yuejuan Zheng _{1,

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Affiliation

Mϕs are the main innate immune cells in the lung at homeostasis, with important roles in host defence and immune modulation. Alveolar Mϕs (AMs) and interstitial Mϕs (IMs) are the two lung Mϕ subsets, so called according to the sites they reside in. These subsets are also defined by their origins and immunological microenvironment, which endow these cells with distinct features and plasticity. This review summarizes the latest definitions and functions of lung Mϕs during homeostasis and provides exemplar of their divergent roles in lung fibrosis.

中文翻译：

肺泡和肺间质巨噬细胞：定义、功能和在肺纤维化中的作用

Mφs 是肺内稳态的主要先天免疫细胞，在宿主防御和免疫调节中具有重要作用。肺泡 Mφs (AMs) 和间质 Mφs (IMs) 是两个肺 Mφs 子集，根据它们所在的部位而得名。这些子集也由它们的起源和免疫微环境定义，这赋予这些细胞不同的特征和可塑性。本综述总结了动态平衡过程中肺 Mφs 的最新定义和功能，并提供了它们在肺纤维化中不同作用的范例。

更新日期：2020-11-06

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