Our front cover features an H&E staining of core fucosyltransferase (Fut8), which is significantly up‐regulated in lung adenocarcinoma. The image is taken from Zhang et al. (pp. 1820–1833), where the authors report that loss of core fucosylation catalyzed by Fut8 significantly enhanced CD8⁺ cytotoxic T lymphocytes (CTL) activation and cytotoxicity by increasing programmed cell death 1 (PD‐1) ubiquitination which in turn led to the degradation of PD‐1 in the proteasome and more efficient tumor eradication. PD‐1 plays a crucial role in CTL activation and provides antitumor responses. The current work indicates that inhibition of core fucosylation is a unique strategy to down‐regulate PD‐1 expression for the anti‐lung adenocarcinoma immune therapy in the future. The original image was digitally modified for the cover.

中文翻译：

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封面故事：Eur。J.免疫。11'20

我们的封面采用了核心岩藻糖基转移酶（Fut8）的H＆E染色，在肺腺癌中显着上调。该图像取自Zhang等人。（pp。1820–1833），作者报告说，Fut8催化的核心岩藻糖基化损失显着增强了CD8 ⁺通过增加程序性细胞死亡1（PD-1）泛素化来增加细胞毒性T淋巴细胞（CTL）的活化和细胞毒性，进而导致蛋白酶体中PD-1的降解并更有效地根除肿瘤。PD-1在CTL激活中起关键作用，并提供抗肿瘤反应。当前的工作表明，抑制核心岩藻糖基化是降低抗肺腺癌免疫疗法中PD-1表达下调的独特策略。原始图像被数字化地修改为封面。