Human neutrophils swim and phagocytize bacteria,Biology of the Cell

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Human neutrophils swim and phagocytize bacteria
Biology of the Cell ( IF 2.4 ) Pub Date : 2020-11-06 , DOI: 10.1111/boc.202000084
Nicolas Garcia-Seyda _{1,

2} , Valentine Seveau ₁ , Fabio Manca ₁ , Martine Biarnes-Pelicot ₁ , Marie-Pierre Valignat ₁ , Marc Bajénoff ₂ , Olivier Theodoly ₁

Affiliation

Leukocytes migrate in an amoeboid fashion while patrolling our organism in the search for infection or tissue damage. Their capacity to migrate has been proven integrin independent, however, non‐specific adhesion or confinement remain a requisite in current models of cell migration. This idea has been challenged twice within the last decade with human neutrophils and effector T lymphocytes, which were shown to migrate in free suspension, a phenomenon termed swimming. While the relevance of leukocyte swimming in vivo remains under judgment, a growing amount of clinical evidence demonstrates that leukocytes are indeed found in liquid‐filled body cavities, occasionally with phagocyted pathogens, such as in the amniotic fluid, the cerebrospinal fluid (CSF), or the eye vitreous and aqueous humor.

中文翻译：

人类中性粒细胞会游泳并吞噬细菌

白细胞以变形虫的方式迁移，同时在我们的有机体中巡逻以寻找感染或组织损伤。它们的迁移能力已被证明与整联蛋白无关，然而，非特异性粘附或限制仍然是当前细胞迁移模型的必要条件。在过去的十年中，这一想法曾两次受到人类中性粒细胞和效应 T 淋巴细胞的挑战，它们被证明可以自由悬浮迁移，这种现象被称为游泳。虽然白细胞在体内游动的相关性仍有待判断，但越来越多的临床证据表明，白细胞确实存在于充满液体的体腔中，偶尔也有吞噬细胞病原体，例如羊水、脑脊液 (CSF)、或眼玻璃体和房水。

更新日期：2020-11-06

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