Trends in Chemistry ( IF 14.0 ) Pub Date : 2020-11-06 , DOI: 10.1016/j.trechm.2020.10.002 Wenbo Li , Cheng Wang , Yingfang Yao , Congping Wu , Wenjun Luo , Zhigang Zou
Photo-therapeutics have attracted increasing attention for the treatment of tumors because of their controllable and tunable nature and low potential for side effects. Photocatalytic materials triggered by targeted wavelengths of light facilitate the generation of reactive oxygen species for tumor DNA damage, allowing for high efficacy at low radiation doses with limited damage of normal tissues. This short review emphasizes the mechanisms and recent breakthroughs achieved in photocatalytic materials for tumor treatment, mainly focusing on light wavelengths in the respective near-infrared (NIR), UV-vis, and X-ray regions. Lastly, current limitations and future perspectives are also highlighted.
中文翻译:
光催化材料:肿瘤细胞的阿波罗箭
由于光疗法的可控制和可调节的性质以及副作用的可能性低,因此光疗法在肿瘤的治疗上已引起越来越多的关注。由目标波长的光触发的光催化材料促进了对肿瘤DNA损伤的活性氧的生成,从而在低辐射剂量下实现了高效率,而对正常组织的损伤有限。这篇简短的评论重点介绍了用于肿瘤治疗的光催化材料的机理和最近取得的突破,主要集中在各自的近红外(NIR),UV-vis和X射线区域的光波长。最后,还强调了当前的局限性和未来的前景。