Natural bioflavonoids are an essential component of dietary supplements possessing antimicrobial properties. Many of the bioflavonoids have resulted in positive antitumor, anticancer, antibacterial, antifungal, anti-inflammatory properties, but the efficacy remains low due to toxicity at the molecular level whereas antiviral property limits to negative. The synergistic link between nanoscience and flavonoid chemistry enhances the epidemiological properties of flavonoid and also diminish the antimicrobial resistivity (AMR) by forming their hybrid nanocomposites. Nanochemistry uses various nanocomposite and nanomaterials for biosensing the flavonoids and their delivery as a drug. The quercetin flavonoid and its derivatives such as rutin, and myricetin are used for sensing and drug delivery. Quercetin with 15Carbon-5Hydroxyl chemical scaffold has been explored for a few decades for the development of hybrid nanocomposite and nanomaterial with metallic as well as organic nano co-composites. This quercetin flavonoid based hybrid nanocomposites seemed to show a significant effect on In vitro and some animal model processes along with attenuating lipid peroxidation, platelet aggregation, and capillary permeability actions. This review mainly focused on the hybrid nanoscience of quercetin bioflavonoid and its application in numerous biological, material fields with a future perspective.

天然生物类黄酮是具有抗菌特性的膳食补充剂的重要组成部分。许多生物类黄酮具有积极的抗肿瘤、抗癌、抗菌、抗真菌、抗炎特性，但由于分子水平的毒性，功效仍然较低，而抗病毒特性仅限于负面。纳米科学和类黄酮化学之间的协同联系增强了类黄酮的流行病学特性，并通过形成混合纳米复合材料来降低抗菌耐药性（AMR）。纳米化学使用各种纳米复合材料和纳米材料来生物传感类黄酮及其作为药物的输送。槲皮素类黄酮及其衍生物，如芦丁和杨梅素，用于传感和药物输送。几十年来，人们一直在探索具有 15Carbon-5Hydroxyl 化学支架的槲皮素，用于开发混合纳米复合材料以及金属和有机纳米复合材料的纳米材料。这种基于槲皮素类黄酮的杂化纳米复合材料似乎对体外和一些动物模型过程具有显着影响，同时减弱脂质过氧化、血小板聚集和毛细血管通透性作用。本综述主要关注槲皮素生物类黄酮的混合纳米科学及其在众多生物、材料领域的应用，并展望未来。