Abstract Developing new pharmaceutical forms from existing drugs has proven to be an alternative in the face of economic and temporal challenges to develop new drugs. In this work, thermal behavior of diclofenac sodium or ibuprofen loaded sericin and alginate particles was evaluated. The thermal phenomena were verified by Thermogravimetric Analysis, Differential Thermal Analysis and Differential Scanning Calorimetry. In addition, the analysis of Hot Stage Microscopy was performed to visualize the thermal phenomena. It was verified that the drugs maintained their original thermal characteristics after their incorporation, which demonstrates no significant interactions between the drugs and the polymeric matrix. The micrographs of Hot Stage Microscopy showed that the drug remains trapped in the particles, even after its melting. The diclofenac sodium particles were also subjected to the accelerated stability test under forced storage conditions (40 ± 2 °C and 75 ± 5% relative humidity) for 6 months, being evaluated the parameters of incorporation efficiency and release of drug in simulated enteric media, after the storage. Considering the results, the particles remained stable in the studied storage conditions, with reproducible incorporation efficiency and release tests.

中文翻译：

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负载双氯芬酸钠或布洛芬的丝胶和海藻酸盐混合物的热表征和稳定性研究

摘要 面对开发新药的经济和时间挑战，从现有药物开发新的药物形式已被证明是一种替代方法。在这项工作中，评估了双氯芬酸钠或布洛芬负载的丝胶和藻酸盐颗粒的热行为。通过热重分析、差热分析和差示扫描量热法验证了热现象。此外，还进行了热台显微镜分析以可视化热现象。经证实，药物在掺入后仍保持其原始热特性，这表明药物与聚合物基质之间没有显着的相互作用。Hot Stage Microscopy 的显微照片显示，即使在熔化后，药物仍会被困在颗粒中。双氯芬酸钠颗粒还在强制储存条件（40±2℃和75±5%相对湿度）下进行了6个月的加速稳定性试验，评估了在模拟肠溶介质中的掺入效率和药物释放参数，存储后。考虑到结果，颗粒在研究的储存条件下保持稳定，具有可重现的掺入效率和释放测试。