Proper design and fabrication of multifunctional visible-light-induced photocatalysts with high catalytic efficiency is still a huge challenge for the value-added chemicals production and environmental remediation. A novel 3D flower-like hierarchical CoWO₄@Bi₂WO₆ Z-scheme hybrid was successfully fabricated via anchoring CoWO₄ nanoparticls on the 2D nanopetals of Bi₂WO₆ microflower obtained by solvothermal assistant self-assembly. The multifunctional composite could markedly improve photocatalytic H₂O₂ production via two-channel route (oxygen reduction and water oxidation reaction) without using sacrificial agent. Interestingly, 3D CoWO₄@Bi₂WO₆ also displayed a remarkable degradation performance on single (enrofloxacin (ENR), lomefloxacin (LOM) or ciprofloxacin hydrochloride (CIP)) and ternary mixed antibiotics (ENR+LOM+CIP) under visible light irradiation. The outstanding photocatalytic activity was primarily attributed to the 3D hierarchical CoWO₄@Bi₂WO₆ micro-flowers architecture for boosting visible light harvesting, matching energy band gaps, more exposed active sites, formation of Z-scheme based charge-transfer dynamics in a p-n heterostructure, as well as strong oxidation and reduction capability of photoexcited h⁺ and e^-. Therefore, it was believed that the novel multifunctional CoWO₄@Bi₂WO₆ photocatalyst exhibited a potential application in production of H₂O₂ and degradation of organic contaminants, which were more significant for the following purification in industrial production and environmental governance.