Novel environments induce a conflicting emotional approach-withdrawal state that triggers stress-related reactions. Social support through the presence of a highly familiar conspecific buffers the individual against such challenges. Although aversive events seem to be predominantly processed by the right hemisphere, this is still under debate and little is known about functional cerebral asymmetries in nonhuman primates during novelty stress, isolation and social buffering. Here we isolated adult marmoset monkeys in a new open-field arena or in their familiar home-cages to establish hemisphere activity and whether the pairmate’s presence buffers the response. Monkeys socially isolated in either location had higher circulating cortisol levels than non-isolated marmosets, but different hemisphere activity patterns indicated by changes in baseline tympanic membrane temperatures (TMT). The bilateral increase in the monkeys that were isolated in the unfamiliar location may reflect an approach-withdrawal conflict. The left-sided increase in the home-cage isolation group was negatively related to cortisol release, this being potentially associated with a more proactive/approach-prone temperament. Interestingly, TMT and cortisol were unaltered when the pairmate was present. Thus, positive social interaction reduces the perceived intensity of the threat, alters hemisphere asymmetries and blocks the hormonal response to novelty stress, consistent with a buffering effect.

新的环境会诱发一种相互冲突的情绪接近退缩状态，从而引发与压力相关的反应。通过高度熟悉的同种存在而产生的社会支持可以缓冲个人应对此类挑战。尽管厌恶事件似乎主要由右半球处理，但这仍在争论中，并且对非人类灵长类动物在新奇压力、孤立和社会缓冲期间的功能性大脑不对称知之甚少。在这里，我们将成年狨猴隔离在一个新的开放场地或它们熟悉的家笼中，以建立半球活动以及配对的存在是否缓冲了反应。与非隔离的狨猴相比，在任一地点与社会隔离的猴子的循环皮质醇水平更高，但基线鼓膜温度 (TMT) 的变化表明了不同的半球活动模式。在不熟悉的地方隔离的猴子的双侧增加可能反映了接近 - 退出冲突。笼子隔离组左侧的增加与皮质醇释放呈负相关，这可能与更积极主动/倾向于接近的气质有关。有趣的是，当伴侣在场时，TMT 和皮质醇没有改变。因此，积极的社会互动降低了威胁的感知强度，改变了半球的不对称性并阻止了荷尔蒙对新奇压力的反应，与缓冲作用一致。在不熟悉的地方隔离的猴子的双侧增加可能反映了接近 - 退出冲突。笼子隔离组左侧的增加与皮质醇释放呈负相关，这可能与更积极主动/倾向于接近的气质有关。有趣的是，当伴侣在场时，TMT 和皮质醇没有改变。因此，积极的社会互动降低了威胁的感知强度，改变了半球的不对称性并阻止了荷尔蒙对新奇压力的反应，与缓冲作用一致。在不熟悉的地方隔离的猴子的双侧增加可能反映了接近 - 退出冲突。笼子隔离组左侧的增加与皮质醇释放呈负相关，这可能与更积极主动/倾向于接近的气质有关。有趣的是，当伴侣在场时，TMT 和皮质醇没有改变。因此，积极的社会互动降低了威胁的感知强度，改变了半球的不对称性并阻止了荷尔蒙对新奇压力的反应，与缓冲作用一致。当配对出现时，TMT 和皮质醇没有改变。因此，积极的社会互动降低了威胁的感知强度，改变了半球的不对称性并阻止了荷尔蒙对新奇压力的反应，与缓冲作用一致。当配对出现时，TMT 和皮质醇没有改变。因此，积极的社会互动降低了威胁的感知强度，改变了半球的不对称性并阻止了荷尔蒙对新奇压力的反应，与缓冲作用一致。