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Clusterkopfschmerzen – Bewährtes und Neues
Der Schmerz ( IF 1.1 ) Pub Date : 2020-11-06 , DOI: 10.1007/s00482-020-00512-7
Charly Gaul

Trigeminal autonomic cephalalgias are characterized by unilateral headaches accompanied by cranial autonomic symptoms and a sense of restlessness. Clinical trials have been conducted on acute therapy and prophylaxis of cluster headache in recent years. Since the other trigeminal autonomic cephalalgias are rare, it is virtually impossible to conduct controlled clinical trials for their investigation. Recent trials provide data on the efficacy of prednisolone, galcanezumab, fremanzeumab and noninvasive vagal nerve stimulation. Methodological difficulties arise in terms of patient recruitment for clinical trials, clinical endpoints and potential differences in the pathophysiology of episodic and chronic cluster headache.

中文翻译:

Clusterkopfschmerzen – Bewährtes und Neues

三叉神经自主性头痛的特点是单侧头痛,伴有颅自主神经症状和烦躁感。近年来,针对丛集性头痛的急性治疗和预防进行了临床试验。由于其他三叉神经自主神经性头痛很少见,因此几乎不可能进行对照临床试验进行研究。最近的试验提供了关于泼尼松龙、galcanezumab、fremanzeumab 和无创迷走神经刺激疗效的数据。在临床试验的患者招募、临床终点以及发作性和慢性丛集性头痛的病理生理学的潜在差异方面出现了方法学上的困难。
更新日期:2020-11-06
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