Vesicles comprising dimethyl aminopropyl octadecanamide (DMAPODA), stearic acid (SA), and carboxyhexadecyl disulfide (CHDDS) were prepared as reduction-responsive carriers. Vesicular particles were found on TEM micrographs and the diameter fell within 100-400 nm. The hydrodynamic mean diameter increased with increasing the content of CHDDS. The zeta potential was lowered by the incorporation of CHDDS into the vesicular membrane. Vesicle whose DMAPODA/SA/ CHDDS molar ratio was 1/1/5 exhibited one endothermic peak around 50.9°C, indicating that the vesicular membrane was homogeneous in the composition. Strong signals were found in 500-540 cm^-1 in the Raman spectrum of vesicles, suggesting that the disulfide lipid (i.e. CHDDS) was incorporated into the vesicular membranes. Vesicles containing CHDDS released rhodamine B in dithiothreitol (DTT, a reducing agent) concentration-dependent manner. The DTTsensitivity of the vesicles in terms of release was higher as the CHDDS content was higher.

制备包含二甲基氨基丙基十八酰胺（DMAPODA），硬脂酸（SA）和羧基十六烷基二硫化物（CHDDS）的囊泡作为还原反应性载体。在TEM显微照片上发现了囊状颗粒，其直径落在100-400nm之内。流体动力学平均直径随CHDDS含量的增加而增加。通过将CHDDS掺入囊泡膜中来降低ζ电位。DMAPODA / SA / CHDDS摩尔比为1/1/5的囊泡在50.9℃附近显示一个吸热峰，表明该囊泡膜在组合物中是均匀的。在囊泡的拉曼光谱中，在500-540 cm ^-1处发现强信号，表明二硫化物脂质（即CHDDS）合并到囊泡膜中。含有CHDDS的囊泡以二硫苏糖醇（DTT，还原剂）浓度依赖性方式释放若丹明B。随着CHDDS含量的增加，囊泡对释放的DTT敏感性更高。