microRNAs (miRNAs) can play a role in a variety of physiological and pathological regulation, and its role is achieved by regulating the expression of target genes. Our previous high-throughput sequencing found that ssc-miR-185 plays an important regulatory role in piglet diarrhea, but its specific target genes and functions in intestinal porcine epithelial cell (IPEC-J2) are still unclear. We intended to verify the target relationship between porcine miR-185 and cell division cycle 42 (CDC42) gene in IPEC-J2, and explored the effect of miR-185 on the proliferation of IPEC-J2 cells.

中文翻译：

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ssc-miR-185靶向CDC42并促进猪肠上皮细胞的增殖。


microRNA（miRNA）可以发挥多种生理和病理调节作用，其作用是通过调节靶基因的表达来实现的。我们前期的高通量测序发现ssc-miR-185在仔猪腹泻中发挥重要的调控作用，但其在猪肠上皮细胞（IPEC-J2）中的具体靶基因和功能尚不清楚。我们旨在验证猪miR-185与IPEC-J2细胞分裂周期42（CDC42）基因之间的靶关系，并探讨miR-185对IPEC-J2细胞增殖的影响。