A convenient approach for antibacterial polypeptoids featuring sulfonium and oligo(ethylene glycol) subunits,Biomaterials Science

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A convenient approach for antibacterial polypeptoids featuring sulfonium and oligo(ethylene glycol) subunits
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-11-05 , DOI: 10.1039/d0bm01384f
Bo Zhang _{1,

2,

3,

4,

5} , Min Li _{1,

2,

3,

4,

5} , Min Lin _{1,

2,

3,

4,

5} , Xuan Yang _{5,

6,

7,

8} , Jing Sun _{1,

2,

3,

4,

5}

Affiliation

Bioinspired polypeptoids show great potential in many applications. Here, we report a convenient approach to synthesize a novel type of polypeptoid containing both sulfonium and oligo(ethylene glycol) (OEG) moieties by ring-opening polymerization (ROP) and a post-modification strategy. Three types of epoxides with (OEG)_n (n = 1–3) groups are involved to offer various functionalities. The obtained polypeptoid sulfonium salts show positive ζ potential, irrespective of the solution pH and the degree of polymerization (DP). We demonstrate that the polypeptoids exhibit excellent antibacterial activity against Staphylococcus aureus (S. aureus) with MIC (minimal inhibitory concentration) in the range of 3.9–7.8 μg mL⁻¹. In addition, the polypeptoids have a low hemolysis property and good in vitro biocompatibility. Remarkably, the as-prepared polypeptoids show rapid and potent antibacterial activity within 5 min. These features suggest that the obtained polypeptoids offer great potential for antimicrobial agents.

中文翻译：

一种具有sulf和低聚（乙二醇）亚基的抗菌多肽的简便方法

受生物启发的类肽在许多应用中显示出巨大的潜力。在这里，我们报告了一种方便的方法，通过开环聚合（ROP）和修饰后的策略来合成新型的同时包含ept和低聚（乙二醇）（OEG）部分的类肽。具有（OEG）_n（n = 1-3）基团的三种类型的环氧化物涉及提供各种功能。无论溶液的pH值和聚合度（DP）如何，所得的类肽sulf盐都显示出正的ζ电势。我们证明，类肽对金黄色葡萄球菌（金黄色葡萄球菌）表现出优异的抗菌活性，MIC（最低抑制浓度）范围为3.9–7.8μgmL ^-1。另外，该类多肽具有低溶血性和良好的体外生物相容性。值得注意的是，所制备的类肽在5分钟内显示出快速有效的抗菌活性。这些特征表明，所获得的类肽为抗菌剂提供了巨大的潜力。

更新日期：2020-11-05

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