A photothermally-induced HClO-releasing nanoplatform for imaging-guided tumor ablation and bacterial prevention,Biomaterials Science

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A photothermally-induced HClO-releasing nanoplatform for imaging-guided tumor ablation and bacterial prevention
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-10-23 , DOI: 10.1039/d0bm01629b
Menglong Zhao _{1,

2,

3,

4,

5} , Wei Feng _{1,

2,

3,

4,

5} , Chang Li _{1,

2,

3,

4,

5} , Weijun Xiu _{1,

2,

3,

4,

5} , Mingdang Li _{1,

2,

3,

4,

5} , Shujuan Liu _{1,

2,

3,

4,

5} , Lianhui Wang _{1,

2,

3,

4,

5} , Wei Huang _{6,

7,

8,

9,

10} , Qiang Zhao _{1,

2,

3,

4,

5}

Affiliation

Photothermal therapy (PTT) is a cure that can inhibit tumor growth effectively and even remove tumor via photo-induced local hyperthermia. However, its shortcoming lies in the fact that excessive heat is most likely to lead to thermal injury at the epidermis of the tumor region and even the area of the surrounding tissue. As a consequence, the exposure of the thermally-induced wound would result in the increased risk of bacterial infection. To date, few PTT platforms have attached importance to the prevention of bacterial infection at the photothermally-induced wound. Herein, we reported a thermally-sensitive liposome nanosystem (Lipo-B-TCCA) containing aza-BODIPY and trichloroisocyanuric acid, which is conductive for the PTT of tumor and the prevention of bacteria. It is observed that the designed nanoplatform could exhibit remarkable stability, high photothermal conversion efficiency (31.4%), and efficient HClO-releasing ability in vitro and in vivo. Moreover, Lipo-B-TCCA is able to eliminate tumor efficiently via near infrared fluorescence and photothermal imaging guidance with low side effects. Most importantly, Lipo-B-TCCA could prevent the growth of S. aureus in the thermal wound during the process of PTT. The imaging-guided photothermally-induced HClO-releasing PTT nanoplatform for tumor ablation and bacterial prevention shows excellent performance and great potential for biomedical applications.

中文翻译：

光热诱导释放HClO的纳米平台，用于成像指导的肿瘤消融和细菌预防

光热疗法（PTT）是一种可以有效抑制肿瘤生长，甚至可以通过光诱导的局部热疗去除肿瘤的疗法。然而，其缺点在于以下事实：过多的热量最有可能导致肿瘤区域的表皮甚至周围组织区域的热损伤。结果，热致伤口的暴露将导致细菌感染的风险增加。迄今为止，很少有PTT平台重视预防光热诱导伤口的细菌感染。在这里，我们报道了一种热敏脂质体纳米系统（Lipo-B-TCCA）含有aza-BODIPY和三氯异氰尿酸，对肿瘤的PTT和细菌的预防具有导电作用。观察到，所设计的纳米平台在体外和体内均可表现出显着的稳定性，高的光热转化效率（31.4％）和有效的HClO释放能力。此外，Lipo-B-TCCA能够通过近红外荧光和光热成像指导有效消除肿瘤，且副作用小。最重要的是，Lipo-B-TCCA可以阻止金黄色葡萄球菌的生长在PTT过程中的热伤口中。用于肿瘤消融和细菌预防的影像引导光热诱导释放HClO的PTT纳米平台表现出卓越的性能，在生物医学应用中具有巨大潜力。

更新日期：2020-11-05

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