Migraine is a throbbing condition, usually associated with nausea and vomiting and requires concurrent administration of anti-migraine along with anti-emetic therapy. The current study was undertaken with an aim to fabricate fast dissolving oral strips (FDOSs) containing Sumatriptan succinate (anti-migraine) and Metoclopramide HCl (anti-emetic) in combination without involving any superdisintegrant. Hydrophilic polymer polyvinyl alcohol (PVA) was used alone with three concentrations of 100, 125, and 150 mg using variable concentrations of glycerol. The solvent casting technique was employed to formulate FDOSs and were evaluated for surface morphology, mechanical properties, surface pH, % moisture content, disintegration time (DT), total dissolving time (TDT), drug contents, and dissolution profile. PVA (150 mg) with 5% glycerol concentration gave best formulation results. FDOSs have exhibited good tensile strength with smooth and uniform surface morphology. DT was ranged from 7.7 to 28 s; while TDT was from 26.4 to 77.6 s. Both polymer and plasticizer concentrations were found to be influencing the characteristics of the strips. Dissolution studies were carried out in distilled water for 15 min and all the formulations have shown released more than 50% drug within first 2 min thereby highlighting the usefulness of FDOSs for the delivery of both drugs in combination significantly. Optimized combination of ingredients was found to be suitable for the formulation of FDOSs for simultaneous delivery of Metoclopramide HCl and Sumatriptan succinate.

偏头痛是一种抽痛症状，通常与恶心和呕吐有关，需要同时服用抗偏头痛药物和止吐治疗。目前的研究目的是制造含有琥珀酸舒马普坦（抗偏头痛）和盐酸甲氧氯普胺（止吐）的快速溶解口服贴片（FDOS），而不涉及任何超级崩解剂。单独使用亲水性聚合物聚乙烯醇 (PVA)，使用不同浓度的甘油，分为 100、125 和 150 mg 三种浓度。采用溶剂浇铸技术来配制 FDOS，并评估其表面形态、机械性能、表面 pH 值、水分含量百分比、崩解时间 (DT)、总溶解时间 (TDT)、药物含量和溶出曲线。甘油浓度为 5% 的 PVA (150 mg) 给出了最佳配方结果。FDOS表现出良好的拉伸强度和光滑、均匀的表面形态。DT 范围为 7.7 至 28 s；而 TDT 为 26.4 至 77.6 秒。发现聚合物和增塑剂浓度都会影响条带的特性。在蒸馏水中进行 15 分钟的溶出度研究，所有制剂均显示在前 2 分钟内释放了超过 50% 的药物，从而突出了 FDOS 在联合递送两种药物方面的有用性。研究发现，优化的成分组合适用于同时递送盐酸甲氧氯普胺和琥珀酸舒马普坦的 FDOS 制剂。