The Role of Virus-Like Particles in Medical Biotechnology,Molecular Pharmaceutics

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The Role of Virus-Like Particles in Medical Biotechnology
Molecular Pharmaceutics ( IF 4.5 ) Pub Date : 2020-11-05 , DOI: 10.1021/acs.molpharmaceut.0c00828
Mauricio Comas-Garcia _{1,

2,

3} , Mayra Colunga-Saucedo ₂ , Sergio Rosales-Mendoza _{4,

5}

Affiliation

Virus-like particles (VLPs) are protein-based, nanoscale, self-assembling, cage architectures, which have relevant applications in biomedicine. They can be used for the development of vaccines, imaging approaches, drug and gene therapy delivery systems, and in vitro diagnostic methods. Today, three relevant viruses are targeted using VLP-based recombinant vaccines. VLP-based drug delivery, nanoreactors for therapy, and imaging systems are approaches under development with promising outcomes. Several VLP-based vaccines are under clinical evaluation. Herein, an updated view on the VLP-based biomedical applications is provided; advanced methods for the production, functionalization, and drug loading of VLPs are described, and perspectives for the field are identified.

中文翻译：

病毒样颗粒在医学生物技术中的作用

病毒样颗粒（VLP）是基于蛋白质的、纳米级的、自组装的、笼状结构，在生物医学中具有相关应用。它们可用于开发疫苗、成像方法、药物和基因治疗递送系统以及体外诊断方法。今天，使用基于 VLP 的重组疫苗靶向三种相关病毒。基于 VLP 的药物递送、用于治疗的纳米反应器和成像系统是正在开发的方法，并取得了可喜的成果。几种基于 VLP 的疫苗正在临床评估中。在此，提供了基于 VLP 的生物医学应用的更新视图；描述了 VLP 的生产、功能化和载药的先进方法，并确定了该领域的前景。

更新日期：2020-12-07

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