Rational Design of Hydrogels to Enhance Osteogenic Potential,Chemistry of Materials

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Rational Design of Hydrogels to Enhance Osteogenic Potential
Chemistry of Materials ( IF 7.2 ) Pub Date : 2020-11-05 , DOI: 10.1021/acs.chemmater.0c03018
Soyon Kim ₁ , Min Lee _{1,

2}

Affiliation

Bone tissue engineering (BTE) encompasses the field of biomaterials, cells, and bioactive molecules to successfully guide the growth and repair of bone tissue. Current BTE strategies rely on delivering osteogenic molecules or cells via scaffolding materials. However, growth factor- and stem cell-based treatments have several limitations, such as source restriction, low stability, difficulties in predicting long-term efficacy, and high costs, among others. These issues have promoted the development of material-based therapy with properties of accessibility, high stability, tunable efficacy, and low-cost production. Hydrogels are widely used in BTE applications because of their unique hydrophilic nature and tunable physicochemical properties to mimic the native bone environment. However, current hydrogel materials are not ideal candidates due to minimal osteogenic capability on their own. Therefore, recent studies of BTE hydrogels attempt to counterbalance these issues by modifying their biophysical properties. In this article, we review recent progress in the design of hydrogels to instruct osteogenic potential and present strategies developed to precisely control its bone healing properties.

中文翻译：

合理设计水凝胶以增强成骨潜力

骨组织工程（BTE）涵盖生物材料、细胞和生物活性分子领域，可成功引导骨组织的生长和修复。目前的 BTE 策略依赖于通过支架材料传递成骨分子或细胞。然而，基于生长因子和干细胞的治疗有一些局限性，例如来源限制、稳定性低、难以预测长期疗效以及成本高等。这些问题促进了基于材料的疗法的发展，其具有可及性、高稳定性、可调功效和低成本生产的特性。水凝胶因其独特的亲水性和可调节的物理化学性质以模仿天然骨骼环境而广泛应用于 BTE 应用。然而，由于其本身的成骨能力极小，目前的水凝胶材料并不是理想的候选材料。因此，最近对 BTE 水凝胶的研究试图通过改变其生物物理特性来平衡这些问题。在本文中，我们回顾了水凝胶设计的最新进展，以指导成骨潜力，并提出了精确控制其骨愈合特性的策略。

更新日期：2020-11-25

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