Abstract

As the largest organ of the body, human skin is multifunctional and enjoys two layers, the epidermis and the dermis, the separation of which is performed by a basement membrane zone. Skin protects the body against mechanical forces and infections. Skin wounds represent large and growing challenges to the healthcare systems globally. Skin wound healing, as a protective shield for the body against the external environment, includes interactions among cell types, the neurovascular system, cytokines, and matrix remodeling. Growth factors (GFs) affect the microenvironment of the wound, and cause rises in cell differentiation, proliferation, and migration. Administrating exogenous GFs has revealed potential in enhancing wound healing outcomes. The use of human GFs in the field of wound healing is becoming gradually more interesting, because of the low-invasive techniques required for their use. Reviewed here are the literatures on the healing of skin wounds with emphasize on the role of GFs and their future prospects, containing profits, and probable long-standing side effects accompanied with their use.

摘要

作为人体最大的器官，人体皮肤是多功能的，分为表皮和真皮两层，由基底膜区分开。皮肤保护身体免受机械力和感染。皮肤伤口是全球医疗保健系统面临的巨大且日益严峻的挑战。皮肤伤口愈合作为身体抵御外部环境的保护屏障，包括细胞类型、神经血管系统、细胞因子和基质重塑之间的相互作用。生长因子 (GFs) 会影响伤口的微环境，并导致细胞分化、增殖和迁移的增加。施用外源性 GF 已显示出增强伤口愈合结果的潜力。人类GFs在伤口愈合领域的应用正变得越来越有趣，因为它们的使用需要低侵入性技术。这里回顾了关于皮肤伤口愈合的文献，强调了 GFs 的作用及其未来前景，包含利润，以及伴随其使用的可能长期存在的副作用。