ABSTRACT

Transient receptor potential melastatin 8 (TRPM8) channels play a central role in the detection of environmental cold temperatures in the somatosensory system. TRPM8 is found in a subset of unmyelinated (C-type) afferents located in the dorsal root (DRG) and trigeminal ganglion (TG). Cold hypersensitivity is a common symptom of neuropathic pain conditions caused by cancer therapy, spinal cord injury, viral infection, multiple sclerosis, diabetes, or withdrawal symptoms associated with chronic morphine treatment. Therefore, TRPM8 has received great attention as a therapeutic target. However, as the activity of TRPM8 is unique in sensing cool temperature as well as warming, it is critical to understand the signaling transduction pathways that control modality-specific activity of TRPM8 in healthy versus pathological settings. This review summarizes recent advances in our understanding of the mechanisms involved in the regulation of the TRPM8 activity.

摘要

瞬态受体潜在的褪黑素8（TRPM8）通道在体感系统的环境低温检测中起着核心作用。在位于背根（DRG）和三叉神经节（TG）的无髓（C型）传入子集中发现TRPM8。感冒超敏反应是由癌症治疗，脊髓损伤，病毒感染，多发性硬化症，糖尿病或与吗啡治疗相关的戒断症状引起的神经性疼痛症状的常见症状。因此，TRPM8作为治疗靶标受到了极大的关注。但是，由于TRPM8的活性在感测凉爽的温度和变暖方面是独特的，因此了解在健康与病理环境中控制TRPM8特定于模式的活性的信号转导途径至关重要。