Estrogen (E2) is one of the main steroid hormones associated with pregnancy and parturition. High levels of E2 increase uterine contractions, promote fetal membrane weakening, and induce degradation of the cervical extracellular matrix (ECM). Current evidence supports the role of E2 in epithelial‐to‐mesenchymal transition (EMT) and inflammation in different cell types; however, its effects on the cellular components of the cervix are still unknown.

中文翻译：

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妊娠期雌二醇水平对宫颈上皮和基质细胞细胞转化、迁移和炎症的影响

雌激素 (E2) 是与妊娠和分娩相关的主要类固醇激素之一。高水平的 E2 会增加子宫收缩，促进胎膜变弱，并诱导宫颈细胞外基质 (ECM) 降解。目前的证据支持 E2 在不同细胞类型的上皮间质转化 (EMT) 和炎症中的作用；然而，它对子宫颈细胞成分的影响仍然未知。