负载前药的碳化锆纳米片作为有效治疗癌症的新型生物光子纳米平台,Advanced Science

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负载前药的碳化锆纳米片作为有效治疗癌症的新型生物光子纳米平台
Advanced Science ( IF 14.3 ) Pub Date : 2020-11-05 , DOI: 10.1002/advs.202001191
Quan Liu _{1,

2} , Zhongjian Xie _{3,

4} , Meng Qiu _{3,

5} , Inseob Shim ₆ , Yunlong Yang _{7,

8} , Sisi Xie ₈ , Qinhe Yang ₉ , Dou Wang _{1,

2} , Shiyou Chen ₃ , Taojian Fan ₃ , Bo Ding ₁₀ , Ziheng Guo ₁₁ , Dickson Adah _{12,

13} , Xinhuang Yao ₁ , Yuhua Zhang ₁ , Hong Wu ₁ , Zongze Wu ₁ , Chaoying Wei ₁ , Hongzhong Wang ₁ , Hyeong Seok Kim ₆ , Qingshuang Zou ₁ , Qiaoting Yan ₁ , Zhen Cai ₁₄ , Jong Seung Kim ₆ , Li-Ping Liu _{1,

15} , Han Zhang ₃ , Yihai Cao ₇

Affiliation

Department of Hepatobiliary and Pancreas Surgery The 2nd Clinical Medical College (Shenzhen People's Hospital) of Jinan University Shenzhen 518020 P. R. China.
Integrated Chinese and Western Medicine Postdoctoral Research Station Jinan University Guangzhou Guangdong 510632 P. R. China.
Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University and Collaborative Innovation Center for Optoelectronic Science and Technology of Shenzhen University Shenzhen 518060 P. R. China.
Shenzhen International Institute for Biomedical Research Shenzhen 518116 P. R. China.
Key Laboratory of Marine Chemistry Theory and Technology (Ocean University of China) Ministry of Education Qingdao 266100 P. R. China.
Department of Chemistry Korea University Seoul 02841 Korea.
Department of Microbiology Tumor and Cell Biology Karolinska Institute Stockholm 17177 Sweden.
Department of Cellular and Genetic Medicine School of Basic Medical Sciences Fudan University Shanghai 200032 P. R. China.
School of Traditional Chinese Medicine Jinan University Guangzhou Guangdong 510632 P. R. China.
Department of Respiratory Disease The Fourth Hospital of Jinan Jinan Shandong 250031 P. R. China.
Department of Pancreatic Surgery West China School of Medicine Sichuan University Chengdu 610041 P. R. China.
State Key Laboratory of Respiratory Disease Department of Infection and Immunity Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Guangdong 510530 P. R. China.
University of Chinese Academy of Sciences Beijing 100049 P. R. China.
Department of clinical laboratory Shenzhen Sun Yat-sen Cardiovascular Hospital Shenzhen Guangdong 518020 P. R. China.
Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis Shenzhen Guangdong 518020 P. R. China.

传统化疗和光热疗法（PTT）面临许多重大挑战，包括全身毒性、低生物利用度、无效的组织渗透、化疗/热疗诱导的炎症和肿瘤血管生成。多功能纳米医学提供了一个令人兴奋的机会来规避上述限制，使其成功转化为临床实践。在此，开发了一种有前景的生物光子纳米平台，基于碳化锆（ZrC）纳米片作为深度 PTT 光敏剂和按需设计的抗癌前药 SN38-Nif，该药物通过光热和肿瘤过度表达的酯酶释放和激活。体外和体内实验证据表明，集成的 ZrC@prodrug 生物光子纳米平台通过专门针对恶性细胞、化疗/热疗诱导的肿瘤炎症和血管生成，具有有效的抗癌作用。在小鼠模型中，ZrC@prodrug 系统显着抑制肿瘤复发、转移、炎症和血管生成。这些发现揭示了一种有前途的癌症精准治疗生物光子策略。

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更新日期：2020-12-16

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