Abstract A new series of 1,3,4-Oxadiazole linked Resveratrol (9a-j) have been synthesized and characterized by 1HNMR, 13CNMR, ESI-MS spectral analysis. The in vitro cytotoxicity effects of synthesized compounds were evaluated against four different human cancer cells including MCF-7, MDA MB-231 (Breast) and A549 (Lung) cell lines. The biological results showed that most of the compounds significantly prevented the proliferation of tested cancer cells.In particular, compound 9b and 9j showed potent anticancer activities against MCF-7 (IC50 = 1.56, 0.45 µM, respectively), A549 (IC50 = 0.11, 1.11 µM, respectively) MDA-MB-231 (IC50 = 1.22, 1.98 µM, respectively). Molecular docking studies revealed that compound 9b selectively occupy the colchicine binding site of the tubulin polymer.

中文翻译：

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1,3,4-恶二唑连接的白藜芦醇衍生物的合成、抗癌评价和分子对接研究

摘要 合成了一个新系列的1,3,4-恶二唑连接的白藜芦醇(9a-j)，并通过1HNMR、13CNMR、ESI-MS 光谱分析对其进行了表征。针对四种不同的人类癌细胞，包括 MCF-7、MDA MB-231（乳房）和 A549（肺）细胞系，评估了合成化合物的体外细胞毒性作用。生物学结果表明，大多数化合物显着阻止了受试癌细胞的增殖。特别是化合物 9b 和 9j 对 MCF-7（IC50 分别为 1.56、0.45 µM）、A549（IC50 = 0.11，分别为 1.11 µM）MDA-MB-231（分别为 IC50 = 1.22、1.98 µM）。分子对接研究表明，化合物 9b 选择性地占据了微管蛋白聚合物的秋水仙碱结合位点。