Four new homoverrucosane-type diterpenes (1–4) and two known analogs (5–6) were isolated from the marine sponge Halichondria sp. Their structures including absolute configurations were determined by combination of spectroscopic analyses, theoretical calculations and comparison with data of literatures. The cytotoxicity against human multiple myeloma cell line RPMI-8266 of compounds 1–4 was evaluated, but none showed activity (IC₅₀ > 10 μM). It was the first report that homoverrucosanes isolated from the marine sponge Halichondria sp.

中文翻译：

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海洋海绵Halichondria sp中的四种高维二十烷型二萜

四个新homoverrucosane型双萜（1 - 4）和两个已知类似物（5 - 6）从海绵中分离Halichondria藻。通过光谱分析，理论计算以及与文献数据的比较，确定了它们的结构，包括绝对构型。针对人多发性骨髓瘤细胞系RPMI-8266化合物的细胞毒性1 - 4进行了评价，但是，没有表现出活性（IC ₅₀  >10μM）。这是首次报道从海洋海绵Halichondria sp。分离出高白二十烷。