Infection is a significant risk factor for failed healing of bone and other tissues. We have developed a sol-gel (solution-gelation) derived bioactive glass doped with silver ions (Ag-BG), tailored to provide non-cytotoxic antibacterial activity while significantly enhancing osteoblast-lineage cell growth in vitro and bone regeneration in vivo. Our objective was to engineer a biomaterial that combats bacterial infection while maintaining the capability to promote bone growth. We observed that Ag-BG inhibits bacterial growth and potentiates the efficacy of conventional antibiotic treatment. Ag-BG microparticles enhance cell proliferation and osteogenic differentiation in human bone marrow stromal cells (hBMSC) in vitro. Moreover, in vivo tests using a calvarial defect model in mice demonstrated that Ag-BG microparticles induce bone regeneration. This novel system with dual biological and advanced antibacterial properties is a promising therapeutic for combating resistant bacteria while triggering new bone formation.

感染是骨骼和其他组织愈合失败的一个重要危险因素。我们开发了一种掺杂银离子 (Ag-BG) 的溶胶-凝胶（溶液-凝胶）衍生生物活性玻璃，旨在提供非细胞毒性抗菌活性，同时显着增强体外成骨细胞谱系细胞生长和体内骨再生。我们的目标是设计一种生物材料，能够抵抗细菌感染，同时保持促进骨骼生长的能力。我们观察到 Ag-BG 抑制细菌生长并增强传统抗生素治疗的功效。 Ag-BG 微粒在体外增强人骨髓基质细胞 (hBMSC) 的细胞增殖和成骨分化。此外，使用小鼠颅骨缺损模型进行的体内测试表明，Ag-BG 微粒可诱导骨再生。这种具有双重生物学和先进抗菌特性的新型系统是一种很有前途的治疗方法，可以对抗耐药细菌，同时触发新骨形成。