Three ligands containing selenium were synthesized by refluxing 3-acetylcoumarin (AC), 3-acetylbenzocoumarin (ABC) and acetobenzylsulfonamide (ABS) with selenosemicarbazide. The synthesized ligands were reacted with two metal salts namely; copper(II) nitrate and potassium teterachloroplatinate(II). The obtained copper and platinium complexes were characterized by different spectroscopic techniques including, ¹H-NMR, ¹³C-NMR, IR, UV-visible, ESR and MS. The biological activity of newly synthesized compounds were evaluated using different testes likes in-vitro antimicrobial screening, anticancer, glutathione-S-transferase and Catalase activities. The in-vitro cytotoxicity against human breast cancer cell line (MCF-7), human liver cancer cell line (HepG-2) and human colon cancer cell line (HCT-116) and Human normal melanocytes (HFB 4) was investigated, where some of the tested compounds were equipotent, while the others were more potent compared with 5-flurouracil and cis-platin as reference drugs. The obtanined results showed that the best results were for copper(II) complexes and especially for benzocoumarin ligand.

通过使3-乙酰香豆素（AC），3-乙酰苯并香豆素（ABC）和乙酰苄基磺酰胺（ABS）与亚硒酰氨基脲一起回流，合成了三个含硒的配体。合成的配体与两种金属盐反应：硝酸铜（II）和四氯铂酸钾（II）。通过不同的光谱技术，包括¹ H-NMR，¹³ C-NMR，IR，UV-可见，ESR和MS，对获得的铜和铂配合物进行表征。使用不同的睾丸，如体外抗菌筛选，抗癌，谷胱甘肽-S-转移酶和过氧化氢酶活性，评估了新合成化合物的生物活性。在体外研究了对人乳腺癌细胞系（MCF-7），人肝癌细胞系（HepG-2），人结肠癌细胞系（HCT-116）和人正常黑素细胞（HFB 4）的细胞毒性，其中一些与5-氟尿嘧啶和顺铂为参比药物相比，这些化合物具有同等效力，而其他化合物则具有更高的效力。变质的结果表明，最好的结果是铜（II）配合物，尤其是苯并香豆素配体。