Antigen-presenting cells participate and are implicated in the pathogenesis of multiple sclerosis. In our study we assessed the frequency of plasmacytoid (pDC) and myeloid (mDC) dendritic cells and the classical, intermediate and non-classical monocytes subsets, as well as their phenotypic and functional profile. We evaluated peripheral blood from relapsing-remitting patients treated with IFN-β in remission and relapse phases and from healthy subjects. In remission, we observed a decrease of mDC/pDC ratio and a return to normal values in relapse. In both phases the frequency of non-classical monocytes decreases. Concerning the phenotypic characterization, an increased HLA-DR expression was observed in remission and a decrease in relapse, revealing alterations in monocytes and dendritic cells homeostasis.

中文翻译：

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复发缓解型多发性硬化患者外周血单核细胞和树突状细胞亚群稳态的改变

抗原呈递细胞参与并参与多发性硬化症的发病机制。在我们的研究中，我们评估了浆细胞样 (pDC) 和髓样 (mDC) 树突状细胞以及经典、中间和非经典单核细胞亚群的频率，以及它们的表型和功能特征。我们评估了在缓解和复发阶段接受 IFN-β 治疗的复发缓解患者和健康受试者的外周血。在缓解期，我们观察到 mDC/pDC 比率下降，并在复发时恢复到正常值。在这两个阶段中，非经典单核细胞的频率都降低了。关于表型特征，在缓解期观察到 HLA-DR 表达增加，复发减少，揭示单核细胞和树突细胞稳态的改变。