Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus,Journal of Chemical Neuroanatomy

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Spexin-expressing neurons in the magnocellular nuclei of the human hypothalamus
Journal of Chemical Neuroanatomy ( IF 2.7 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.jchemneu.2020.101883
Artur Pałasz ₁ , Aleksandra Suszka-Świtek ₁ , Andrzej Kaśkosz ₂ , Danuta Plewka ₃ , Katarzyna Bogus ₁ , Łukasz Filipczyk ₁ , Iwona Błaszczyk ₁ , Flora Bacopoulou ₄ , John J Worthington ₅ , Aneta Piwowarczyk-Nowak ₂ , Marta Tyszkiewicz-Nwafor ₆ , Ryszard Wiaderkiewicz ₁

Affiliation

Neuropeptides are involved in numerous brain activities being responsible for a wide spectrum of higher mental functions. The purpose of this concise, structural and qualitative investigation was to map the possible immunoreactivity of the novel neuropeptide spexin (SPX) within the human magnocellular hypothalamus. SPX is a newly identified peptide, a natural ligand for the galanin receptors (GALR) 2/3, with no molecular structure similarities to currently known regulatory factors. SPX seems to have multiple physiological functions, with an involvement in reproduction and food-intake regulation recently revealed in animal studies. For the first time we describe SPX expressing neurons in the supraoptic (SON) and paraventricular (PVN) nuclei of the human hypothalamus using immunohistochemical and fluorescent methods, key regions involved in the mechanisms of osmotic homeostasis, energy expenditure, consummatory behaviour, reproductive processes, social recognition and stress responses. The vast majority of neurons located in both examined neurosecretory nuclei show abundant SPX expression and this may indirectly implicate a potential contribution of SPX signaling to the hypothalamic physiology in the human brain.

中文翻译：

人下丘脑大细胞核中表达 Spexin 的神经元

神经肽参与许多大脑活动，负责广泛的高级心理功能。这项简洁、结构和定性研究的目的是绘制人类大细胞下丘脑内新型神经肽 spexin (SPX) 可能的免疫反应性。SPX 是一种新发现的肽，是甘丙肽受体 (GALR) 2/3 的天然配体，与目前已知的调节因子没有相似的分子结构。SPX 似乎具有多种生理功能，最近在动物研究中发现与生殖和食物摄入调节有关。我们第一次使用免疫组织化学和荧光方法描述了人类下丘脑视上 (SON) 和室旁 (PVN) 核中表达 SPX 的神经元，参与渗透稳态、能量消耗、消费行为、生殖过程、社会认知和压力反应机制的关键区域。位于两个受检神经分泌核中的绝大多数神经元都显示出丰富的 SPX 表达，这可能间接暗示 SPX 信号传导对人脑下丘脑生理学的潜在贡献。

更新日期：2021-01-01

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