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Automated measurement of pH-dependent solid-liquid equilibria of itaconic acid and protocatechuic acid
Fluid Phase Equilibria ( IF 2.8 ) Pub Date : 2021-03-01 , DOI: 10.1016/j.fluid.2020.112893
Arne Holtz , Jonas Görtz , Christian Kocks , Mark Junker , Andreas Jupke

Abstract Crystallization is a highly selective unit operation capable of separating target molecules from complex media. Its design requires precise solid-liquid equilibrium (SLE) data. The SLE of platform chemicals like carboxylic acids in complex aqueous media depends on temperature, pH value as well as on present side components, but predominantly, only the solubility for different temperatures is reported. This work presents a novel automated method for the determination of the pH- and temperature-dependent SLE in complex media using readily available laboratory equipment. Taking the example of itaconic acid, the pH-dependent solubility for different temperatures is measured and validated with results obtained from the classic excess solid method along with literature data. Using the automated setup, the influence of different loadings of sodium chloride on the SLE of itaconic acid is investigated and a correlation between solubility and concentration of the electrolyte is derived. The SLE data acquired for protocatechuic acid in fermentation medium demonstrates the applicability of the method for the determination of comprehensive SLE in multicomponent mixtures without the requirement of specific analytical methods for the target compound. The resulting SLE data can be used for a more precise design and techno-economic evaluation of crystallization processes in biotechnological production routes.

中文翻译:

衣康酸和原儿茶酸的 pH 依赖性固液平衡的自动测量

摘要 结晶是一种高度选择性的单元操作,能够将目标分子从复杂介质中分离出来。它的设计需要精确的固液平衡 (SLE) 数据。复杂水性介质中羧酸等平台化学品的 SLE 取决于温度、pH 值以及现有的副成分,但主要是报告了不同温度下的溶解度。这项工作提出了一种使用现成的实验室设备测定复杂介质中 pH 值和温度依赖性 SLE 的新型自动化方法。以衣康酸为例,测量不同温度下的 pH 依赖性溶解度,并使用经典过量固体方法获得的结果以及文献数据进行验证。使用自动设置,研究了不同氯化钠负载量对衣康酸 SLE 的影响,并推导出溶解度和电解质浓度之间的相关性。发酵培养基中原儿茶酸的 SLE 数据表明该方法适用于测定多组分混合物中的综合 SLE,而无需对目标化合物采用特定的分析方法。由此产生的 SLE 数据可用于生物技术生产路线中结晶过程的更精确设计和技术经济评估。发酵培养基中原儿茶酸的 SLE 数据表明该方法适用于测定多组分混合物中的综合 SLE,而无需对目标化合物采用特定的分析方法。所得的 SLE 数据可用于对生物技术生产路线中的结晶过程进行更精确的设计和技术经济评估。发酵培养基中原儿茶酸的 SLE 数据表明该方法适用于测定多组分混合物中的综合 SLE,而无需对目标化合物采用特定的分析方法。由此产生的 SLE 数据可用于生物技术生产路线中结晶过程的更精确设计和技术经济评估。
更新日期:2021-03-01
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