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The effect of environmental Bisphenol A exposure on breast cancer associated with obesity
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-11-05 , DOI: 10.1016/j.etap.2020.103544
Ayse Basak Engin , Atilla Engin

Bisphenol A (BPA) is a widely used endocrine disrupter. Its environmental exposure is a causative factor of cell aging via decreasing telomerase activity, thus leading to shortening of telomere length. Epidemiological studies confirm positive associations between BPA exposure and the incidence of obesity and type 2 diabetes (T2DM). Increased urinary BPA levels in obese females are both significantly correlated with shorter relative telomere length and T2DM. BPA is a critically effective endocrine disrupter leading to poor prognosis via the obesity-inflammation-aromatase axis in breast cancer. Environmental BPA exposure contributes to the progression of both estrogen dependent and triple negative breast cancers. BPA is a positive regulator of human telomerase reverse transcriptase (hTERT) and it increases the expression of hTERT mRNA in breast cancer cells. BPA exposure can lead to tamoxifen resistance. Among patients treated with chemotherapy, those with persistent high telomerase activity due to BPA are at higher risk of death.



中文翻译:

环境双酚A暴露对肥胖相关乳腺癌的影响

双酚A(BPA)是一种广泛使用的内分泌干扰物。其环境暴露是通过降低端粒酶活性而导致细胞衰老的原因,从而导致端粒长度缩短。流行病学研究证实BPA暴露与肥胖症和2型糖尿病(T2DM)的发病率呈正相关。肥胖女性的尿液BPA水平升高均与较短的相对端粒长度和T2DM密切相关。BPA是一种非常有效的内分泌干扰物,可通过肥胖症-炎症-芳香化酶轴导致乳腺癌预后不良。暴露于环境中的BPA有助于雌激素依赖性和三阴性乳腺癌的进展。BPA是人类端粒酶逆转录酶(hTERT)的阳性调节剂,可增加hTERT mRNA在乳腺癌细胞中的表达。BPA暴露可导致他莫昔芬耐药。在接受化学疗法治疗的患者中,由于双酚A导致端粒酶活性持续较高的患者死亡风险更高。

更新日期:2020-11-21
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