Exposure to triclosan, an antimicrobial agent, and bisphenol A (BPA), the monomer of polycarbonate plastics, is widespread. Endocrine-disrupting impacts of these chemicals have been demonstrated in in vitro studies, rodent toxicology studies, and some human observational studies. Here we compared urinary concentrations of triclosan and BPA in the Canadian and U.S. populations using nationally-representative data from the 2012–2015 Canadian Health Measures Survey (CHMS) and the 2013–2016 National Health and Nutrition Examination Survey (NHANES). We then examined the cross-sectional associations of urinary triclosan or BPA with serum sex steroid hormones, including estradiol (E2), progesterone (P4), and testosterone (T), using multivariable regression. We observed differences in creatinine-standardized chemical concentrations between countries; urinary triclosan was higher in Canadian females aged 12–19 years, while BPA was higher in U.S. females aged 20–49 years. We also found significant associations among urinary chemicals and serum E2 and T, but not P4. Increasing triclosan was associated with higher levels of E2 in 6–11-year-old girls, but with lower levels of E2 and T in adolescent boys aged 12–19 years. Increasing BPA was associated with lower levels of E2 in 6–11-year-old boys and in adolescents aged 12–19 years of either sex. We observed a U-shaped association between urinary triclosan and E2 in male adults aged 50–79 years; no associations between BPA and hormones were detected in adults. These results, in accordance with the in vitro and animal literature, suggest that triclosan and BPA exposures may be cross-sectionally associated with altered reproductive hormone levels, especially in children and adolescents. Further research and prospective studies are necessary to elucidate country-specific differences in chemical exposures and the potential public health significance of these findings.

广泛接触抗微生物剂三氯生和聚碳酸酯塑料的单体双酚A（BPA）。这些化学物质的内分泌干扰作用已在体外得到证实研究，啮齿动物毒理学研究和一些人类观察性研究。在这里，我们使用2012-2015年加拿大卫生措施调查（CHMS）和2013-2016年国家健康与营养检查（NHANES）的全国代表性数据，比较了加拿大和美国人群中三氯生和BPA的尿液浓度。然后，我们使用多变量回归分析了尿三氯生或BPA与血清性类固醇激素（包括雌二醇（E2），孕酮（P4）和睾丸激素（T））的横断面联系。我们观察到各国之间的肌酐标准化化学浓度存在差异。在12-19岁的加拿大女性中尿三氯生较高，而在20-49岁的美国女性中BPA较高。我们还发现尿液化学物质与血清E2和T之间存在显着关联，但不是P4。三氯生增加与6-11岁女孩的E2水平升高有关，但与12-19岁青少年男孩的E2和T水平较低相关。BPA升高与6-11岁男孩和12-19岁男女青少年的E2水平降低相关。我们观察到年龄在50-79岁的成年男性中尿三氯生和E2之间呈U形关联。在成年人中未发现BPA与激素之间的关联。这些结果，按照 我们观察到年龄在50-79岁的成年男性中尿三氯生和E2之间呈U形关联。在成年人中未发现BPA与激素之间的关联。这些结果，按照 我们观察到年龄在50-79岁的成年男性中尿三氯生和E2之间呈U形关联。在成年人中未发现BPA与激素之间的关联。这些结果，按照体外和动物文献表明，三氯生和BPA的暴露可能与生殖激素水平的改变在横断面上有关，尤其是在儿童和青少年中。有必要进行进一步的研究和前瞻性研究，以阐明特定国家/地区在化学暴露方面的差异以及这些发现的潜在公共卫生意义。