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Single nucleotide polymorphisms within NFKBIA are associated with nasopharyngeal carcinoma susceptibility in Chinese Han population
Cytokine ( IF 3.7 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.cyto.2020.155356 Hanyi Zhang 1 , Siyao Deng 2 , Jiayu Zhang 2 , Guiquan Zhu 3 , Jie Zhou 1 , Wenjing Ye 2 , Qingwei Wang 4 , Yi Wang 4 , Bingwen Zou 5 , Peng Zhang 1 , Shichuan Zhang 1 , Jinyi Lang 6 , Shun Lu 6
Cytokine ( IF 3.7 ) Pub Date : 2021-02-01 , DOI: 10.1016/j.cyto.2020.155356 Hanyi Zhang 1 , Siyao Deng 2 , Jiayu Zhang 2 , Guiquan Zhu 3 , Jie Zhou 1 , Wenjing Ye 2 , Qingwei Wang 4 , Yi Wang 4 , Bingwen Zou 5 , Peng Zhang 1 , Shichuan Zhang 1 , Jinyi Lang 6 , Shun Lu 6
Affiliation
Genes involved in latent membrane protein 1 (LMP1) signaling pathways have been suggested to play an important role in nasopharyngeal carcinogenesis. We investigated potentially functional genetic variants associated with the risk of nasopharyngeal carcinoma (NPC) in genes involved in the LMP1 signaling pathway. Altogether, 73 single nucleotide polymorphisms (SNPs) with MAF ≥ 10% were located within the regions of interest of the four genes TRAF3, NFKBIA, CHUK and MAP2K4. From these, 10 SNPs were selected for genotyping based on LD (r2 ≥ 0.80) in a hospital-based case-control study of 332 NPC cases and 585 healthy controls from the Chinese Han population. Minor allele carriers of the promoter SNP rs2233409 in NFKBIA, had an increased risk of NPC (AA vs GG: OR 7.14, 95%CI, 1.08-34.18, P = 0.04, dominant model). Based on the results, we concluded that rs2233409 polymorphism in NFKBIA may be moderately associated with the risk of NPC. Further studies with larger independent samples and functional analysis are needed to verify our results.
更新日期：2021-02-01
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