Antibacterial hydrogels have attracted extensive attention for preventing bacterial infection as wound dressing. However, development of broad-spectrum antibacterial hydrogel with a specific recognition ability and high strength remains challenging. In this work, a novel multifunctional nanocomposite antibacterial hydrogel with high strength and toughness is prepared by one-pot polymerization of hydrogen bonding monomer N-acryloyl glycinamide (NAGA) mixing with polydopamine-coated gold nanorods (Au@PDA NRs). The PNAGA-Au@PDA hydrogels are then coated with E. coli or S. aureus-pretreated macrophage membrane (termed as E/SMM-PNAGA-Au@PDA). Intriguingly, the resultant hydrogels can recognize specifically the source bacteria, and kill 98% bacteria in vitro under NIR irradiation for 5 min. Importantly, the SMM-PNAGA-Au@PDA hydrogel implanted on the dorsal area of rats can facilitate the infected wound healing and avoid secondary damage during peeling. This tough nanocomposite hydrogel coated with specific bacteria-activated macrophage membrane is promising to be developed as wound dressing, artificial skin and load-bearing scaffolds.

抗菌水凝胶作为伤口敷料在预防细菌感染方面已引起广泛关注。然而，具有特定识别能力和高强度的广谱抗菌水凝胶的开发仍然具有挑战性。在这项工作中，通过将氢键键合单体N-丙烯酰基甘氨酰胺（NAGA）与聚多巴胺涂层的金纳米棒（Au @ PDA NRs）混合一锅法制备了一种具有高强度和韧性的新型多功能纳米复合抗菌水凝胶。然后用大肠杆菌或金黄色葡萄球菌预处理的巨噬细胞膜（称为E / SMM-PNAGA-Au @ PDA）涂覆PNAGA-Au @ PDA水凝胶。有趣的是，所得水凝胶可以特异性识别来源细菌，并在体外杀死98％的细菌在NIR照射下5分钟。重要的是，将SMM-PNAGA-Au @ PDA水凝胶植入大鼠背侧区域可促进感染的伤口愈合，并避免脱皮过程中的继发性损伤。这种具有特殊细菌活化巨噬细胞膜的坚韧纳米复合水凝胶有望被开发为伤口敷料，人造皮肤和承重支架。