Five polymorphisms (rs4713916, rs4713902, rs1360780, rs9296158 and rs3800373) of FKBP5 gene were analyzed in a case–control study comprising 423 Mexican individuals (146 individuals with suicide attempt and 277 controls). The SNP’s were genotyped using the TaqMan-allelic assay. Genotype and allele frequencies were compared between the two groups, then the association between FKBP5 gene polymorphisms and suicide attempt was analyzed. We found a significant association of rs1360780 T minor allele (All, OR = 1.80, 95 % CI = 1.35–2.41, P = 0.0005; Males, OR = 2.25, 95 % CI = 1.44–3.50, P = 0.0002) as a suicide behavior risk factor. Conversely, rs3800373 C minor allele (All, OR = 0.61, 95 % CI = 0.46–0.83; P = 0.0013; Females, OR = 0.33, 95 % CI = 0.22–0.50; P = 0.0001) and the A-C-T-A-C haplotype (OR = 0.06, 95 % CI = 0.01−0.36; P = 0.002) were significantly associated as protective factors. No association was observed with the other SNP’s. Our study suggests that SNP’s in FKBP5 gene contribute to suicide behavior pathogenesis.

FKBP5基因的五种多态性（rs4713916、rs4713902、rs1360780、rs9296158 和 rs3800373）在包括 423 名墨西哥人（146 名有自杀企图的人和 277 名对照者）的病例对照研究中进行了分析。使用 TaqMan 等位基因检测对 SNP 进行基因分型。比较两组的基因型和等位基因频率，然后FKBP5分析了基因多态性和自杀企图。我们发现 rs1360780 T 次要等位基因（全部，OR = 1.80，95% CI = 1.35–2.41，P = 0.0005；男性，OR = 2.25，95% CI = 1.44–3.50，P = 0.0002）与自杀有显着关联行为危险因素。相反，rs3800373 C 小等位基因（全部，OR = 0.61，95% CI = 0.46–0.83；P = 0.0013；女性，OR = 0.33，95% CI = 0.22–0.50；P = 0.0001）和单倍型（ACOR = 0.0001） 0.06, 95% CI = 0.01−0.36; P = 0.002) 与保护因素显着相关。没有观察到与其他 SNP 的关联。我们的研究表明FKBP5基因中的 SNP有助于自杀行为的发病机制。